Patterns of preoptic-hypothalamic neuronal activation and LH secretion in female sheep following the introduction and withdrawal of novel males
| Autor: | Trina Jorre de St Jorre, P.A.R. Hawken, Dominique Blache, Graeme Martin, Christopher J. Scott, Jennifer Rodger, Jeremy Troy Smith, Tammi Esmaili |
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| Rok vydání: | 2019 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Hypothalamus Reproductive technology Neuroendocrinology Biology 03 medical and health sciences Sexual Behavior Animal 0302 clinical medicine Endocrinology Arcuate nucleus Internal medicine Genetics medicine Animals Social Behavior Molecular Biology 030304 developmental biology Neurons 0303 health sciences 030219 obstetrics & reproductive medicine Sheep Lamina terminalis Luteinizing Hormone Preoptic Area Preoptic area medicine.anatomical_structure Ventromedial nucleus of the hypothalamus Reproductive Medicine Social Isolation Animal Science and Zoology Female Luteinizing hormone Developmental Biology Biotechnology |
| Zdroj: | Reproduction, fertility, and development. 31(11) |
| ISSN: | 1031-3613 |
| Popis: | The neuroendocrine response of female sheep to a novel male involves neural activation in the hypothalamus. However, if males are removed, the gonadotrophic signal declines, so the neural activity is likely to change. We examined Fos-immunoreactive (IR) cells in hypothalamic tissues from seasonally anovulatory female sheep exposed to males for 2 or 6h, or for 2h followed by 4h isolation from males. Control females were killed in the absence of male exposure. Male introduction increased LH secretion in all females; male removal was associated with a reduction only in mean and basal LH concentrations. Females exposed to males for 2h had more Fos-IR cells in the arcuate nucleus (ARC), ventromedial nucleus of the hypothalamus (VMH) and organum vasculosum of the lamina terminalis (OVLT) than control females. Fos-IR cells in the preoptic area (POA) were only greater than in control females after 6h exposure to a male. Removal of males decreased the number of Fos-IR cells in the ARC, VMH and OVLT, but not in the POA. Thus, hypothalamic neural activation and LH secretion in female sheep are stimulated by males and decline after male removal. However, activation in the POA persists after removal and may explain the incomplete decline in the LH response. |
| Databáze: | OpenAIRE |
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