Ethanol Preference Is Inversely Correlated With Ethanol-Induced Dopamine Release in 2 Substrains of C57BL/6 Mice
| Autor: | Rueben A. Gonzales, Vorani Ramachandra, Steven Phuc, Ana Crystal Franco |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Microdialysis Alcohol Drinking Dopamine Medicine (miscellaneous) Alcohol Toxicology Basal Ganglia Mice chemistry.chemical_compound Internal medicine medicine Animals Neurotransmitter Ethanol Behavior Animal Dose-Response Relationship Drug Ventral striatum Central Nervous System Depressants Mice Inbred C57BL Psychiatry and Mental health Dose–response relationship medicine.anatomical_structure Endocrinology chemistry Biochemistry Catecholamine medicine.drug |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 31:1669-1676 |
| ISSN: | 1530-0277 0145-6008 |
| DOI: | 10.1111/j.1530-0277.2007.00463.x |
| Popis: | Background: The C57BL/6 mouse model has been used extensively in alcohol drinking studies, yet significant differences in ethanol preference between substrains exist. Differences in ethanol-induced dopamine release in the ventral striatum could contribute to this variability in drinking behavior as dopamine has been implicated in the reinforcing properties of ethanol. Methods: A 2-bottle choice experiment investigated the difference in ethanol preference between C57BL/6J and C57BL/6NCrl animals. Microdialysis was used to determine dopamine release and ethanol clearance in these 2 substrains after intraperitoneal injections of 1.0, 2.0 and 3.0 g/kg ethanol or saline. Results: C57BL/6J mice exhibited significantly greater ethanol preference and less ethanol-stimulated dopamine release compared with C57BL/6NCrl mice. The intraperitoneal injections of ethanol caused a significant increase in dopamine in both substrains at all 3 doses with significant differences between substrains at the 2 highest alcohol doses. Saline injections had a significant effect on dopamine release when given in a volume equivalent to the 3 g/kg ethanol dose. Ethanol pharmacokinetics were similar in the 2 substrains at all 3 doses. Conclusions: Ethanol-induced dopamine release in the ventral striatum may contribute to the differences in alcohol preference between C57BL/6J and C57BL/6NCrl mice. |
| Databáze: | OpenAIRE |
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