Dose ranging study of lansoprazole, a new proton pump inhibitor, in patients with high gastric acid secretion
| Autor: | A. Duchier, F. Dellatolas, P. Molinier, J. Durrel, J. Duchier, Ivan Berlin, A. Cournot |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Lansoprazole Proton-pump inhibitor Peptide hormone Biology 2-Pyridinylmethylsulfinylbenzimidazoles Drug Administration Schedule Gastric Acid Double-Blind Method Oral administration Internal medicine Gastrins medicine Humans Pharmacology (medical) Gastrin Pharmacology Adenosine Triphosphatases Stomach General Medicine Dose-ranging study medicine.anatomical_structure Endocrinology Duodenal Ulcer Gastric acid Female Omeprazole medicine.drug |
| Zdroj: | European journal of clinical pharmacology. 43(2) |
| ISSN: | 0031-6970 |
| Popis: | The effects of single doses and of 7 days of lansoprazole 10, 20 and 30 mg PO versus placebo on gastric acid secretion have been evaluated in 8 patients with high gastric acid secretion. The double blind crossover period was followed by a simple blind 7 days on placebo to detect any rebound phenomenon. After the first dose lansoprazole did not modify basal acid output (BAO) but it significantly and dose dependently inhibited peak acid output (PAO) and increased the time during which nocturnal intragastric pH was greater than 3. After 7 days of treatment the same significant, dose-dependent suppression of gastric acid was found, but BAO was also blocked. One week after cessation of lansoprazole administration no rebound increase in gastric acid-secretion was observed. The plasma gastrin concentration remained unchanged throughout the study. |
| Databáze: | OpenAIRE |
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