Chitosan Oligosaccharide Attenuates Nonalcoholic Fatty Liver Disease Induced by High Fat Diet through Reducing Lipid Accumulation, Inflammation and Oxidative Stress in C57BL/6 Mice

Autor: Geng Wang, Wanjing Sun, Zhiping Xiao, Lujie Liu, Minqi Wang, Wenjing Tao, Xun Pei
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
nonalcoholic fatty liver disease
medicine.medical_specialty
Antioxidant
NF-E2-Related Factor 2
medicine.medical_treatment
Macrophage polarization
Oligosaccharides
Pharmaceutical Science
Inflammation
Diet
High-Fat
Chronic liver disease
medicine.disease_cause
Article
ampk
Mice
03 medical and health sciences
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Internal medicine
Drug Discovery
Nonalcoholic fatty liver disease
medicine
Animals
oxidative stress
Pharmacology
Toxicology and Pharmaceutics (miscellaneous)
lcsh:QH301-705.5
030304 developmental biology
Chitosan
0303 health sciences
Chemistry
lipid accumulation
AMPK
Lipid Metabolism
medicine.disease
Lipids
Mice
Inbred C57BL
Endocrinology
Liver
lcsh:Biology (General)
inflammation
030220 oncology & carcinogenesis
Cytokines
chitosan oligosaccharide
medicine.symptom
Metabolic syndrome
Oxidative stress
Zdroj: Marine Drugs, Vol 17, Iss 11, p 645 (2019)
Marine Drugs
Volume 17
Issue 11
ISSN: 1660-3397
Popis: Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease closely associated with metabolic syndrome, but there are no validated pharmacological therapies. The aim of this study was to investigate the effect of chitosan oligosaccharide (COS) on NAFLD. Mice were fed either a control diet or a high-fat diet (HFD) with or without COS (200 or 400 mg/kg body weight (BW)) by oral gavage for seven weeks. Administration with COS significantly lowered serum lipid levels in the HFD-fed mice. The hepatic lipid accumulation was significantly decreased by COS, which was attributed to decreased expressions of lipogenic genes and increased expressions of fatty &beta
oxidation-related genes. Moreover, pro-inflammatory cytokines, neutrophils infiltration, and macrophage polarization were decreased by COS in the liver. Furthermore, COS ameliorated hepatic oxidative stress by activating the nuclear factor E2-related factor 2 (Nrf2) pathway and upregulating gene expressions of antioxidant enzymes. These beneficial effects were mediated by the activation of the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. Therefore, COS might be a potent dietary supplement to ameliorate NAFLD.
Databáze: OpenAIRE
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