Chitosan Oligosaccharide Attenuates Nonalcoholic Fatty Liver Disease Induced by High Fat Diet through Reducing Lipid Accumulation, Inflammation and Oxidative Stress in C57BL/6 Mice
Autor: | Geng Wang, Wanjing Sun, Zhiping Xiao, Lujie Liu, Minqi Wang, Wenjing Tao, Xun Pei |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
nonalcoholic fatty liver disease medicine.medical_specialty Antioxidant NF-E2-Related Factor 2 medicine.medical_treatment Macrophage polarization Oligosaccharides Pharmaceutical Science Inflammation Diet High-Fat Chronic liver disease medicine.disease_cause Article ampk Mice 03 medical and health sciences 0302 clinical medicine Non-alcoholic Fatty Liver Disease Internal medicine Drug Discovery Nonalcoholic fatty liver disease medicine Animals oxidative stress Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 030304 developmental biology Chitosan 0303 health sciences Chemistry lipid accumulation AMPK Lipid Metabolism medicine.disease Lipids Mice Inbred C57BL Endocrinology Liver lcsh:Biology (General) inflammation 030220 oncology & carcinogenesis Cytokines chitosan oligosaccharide medicine.symptom Metabolic syndrome Oxidative stress |
Zdroj: | Marine Drugs, Vol 17, Iss 11, p 645 (2019) Marine Drugs Volume 17 Issue 11 |
ISSN: | 1660-3397 |
Popis: | Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease closely associated with metabolic syndrome, but there are no validated pharmacological therapies. The aim of this study was to investigate the effect of chitosan oligosaccharide (COS) on NAFLD. Mice were fed either a control diet or a high-fat diet (HFD) with or without COS (200 or 400 mg/kg body weight (BW)) by oral gavage for seven weeks. Administration with COS significantly lowered serum lipid levels in the HFD-fed mice. The hepatic lipid accumulation was significantly decreased by COS, which was attributed to decreased expressions of lipogenic genes and increased expressions of fatty &beta oxidation-related genes. Moreover, pro-inflammatory cytokines, neutrophils infiltration, and macrophage polarization were decreased by COS in the liver. Furthermore, COS ameliorated hepatic oxidative stress by activating the nuclear factor E2-related factor 2 (Nrf2) pathway and upregulating gene expressions of antioxidant enzymes. These beneficial effects were mediated by the activation of the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. Therefore, COS might be a potent dietary supplement to ameliorate NAFLD. |
Databáze: | OpenAIRE |
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