Author Correction: Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories
| Autor: | Brigitta Brandner, Ravi K. Das, Katie Walsh, Grace Gale, H. Valerie Curran, Georges Iskandar, Luke Mordecai, Merel Kindt, Vanessa E Hennessy, Sunjeev K. Kamboj |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcohol Drinking Science General Physics and Astronomy Addiction Harmful drinking Therapeutics General Biochemistry Genetics and Molecular Biology Article Learning and memory Reward Memory Adaptation Psychological medicine Humans Ketamine Psychiatry lcsh:Science Author Correction Multidisciplinary business.industry General Chemistry Treatment Outcome lcsh:Q Female Rewriting business Reinforcement Psychology Biomarkers medicine.drug |
| Zdroj: | Nature Communications Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020) |
| ISSN: | 2041-1723 |
| Popis: | Maladaptive reward memories (MRMs) are involved in the development and maintenance of acquired overconsumption disorders, such as harmful alcohol and drug use. The process of memory reconsolidation - where stored memories become briefly labile upon retrieval - may offer a means to disrupt MRMs and prevent relapse. However, reliable means for pharmacologically weakening MRMs in humans remain elusive. Here we demonstrate that the N-methyl D-aspartate (NMDA) antagonist ketamine is able to disrupt MRMs in hazardous drinkers when administered immediately after their retrieval. MRM retrieval + ketamine (RET + KET) effectively reduced the reinforcing effects of alcohol and long-term drinking levels, compared to ketamine or retrieval alone. Blood concentrations of ketamine and its metabolites during the critical ‘reconsolidation window’ predicted beneficial changes only following MRM reactivation. Pharmacological reconsolidation interference may provide a means to rapidly rewrite maladaptive memory and should be further pursued in alcohol and drug use disorders. Memories linking environmental cues to alcohol reward are involved in the development and maintenance of heavy drinking. Here, the authors show that a single dose of ketamine, given after retrieval of alcohol-reward memories, disrupts the reconsolidation of these memories and reduces drinking in humans. |
| Databáze: | OpenAIRE |
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