The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw

Autor: Hoon Hyun, Sungsu Lee, Sung Ok Hong, Sewook Um, So Yeon Kim, Deok Won Lee, Heung Jae Chun, Dae Hyeok Yang, Gyu Tae Kim
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
bisphosphonate
Administration
Topical
medicine.medical_treatment
Rat model
necrotic bone percentages
Drug Evaluation
Preclinical
Pharmaceutical Science
Article
Bone and Bones
blood vessels
03 medical and health sciences
Polydeoxyribonucleotides
0302 clinical medicine
Salmon
Osteoclast
Internal medicine
Drug Discovery
Animals
Humans
Medicine
Pharmacology
Toxicology and Pharmaceutics (miscellaneous)
lcsh:QH301-705.5
030304 developmental biology
Biological Products
0303 health sciences
business.industry
Necrotic bone
Bisphosphonate
medicine.disease
Spermatozoa
Sperm
Disease Models
Animal
Treatment Outcome
Endocrinology
medicine.anatomical_structure
osteoclasts
lcsh:Biology (General)
Aminopropionitrile
030220 oncology & carcinogenesis
bisphosphonate-related osteonecrosis of the jaw
Bisphosphonate-Associated Osteonecrosis of the Jaw
Rabbits
polydeoxyribonucleotide
business
Osteonecrosis of the jaw
Zdroj: Marine Drugs, Vol 17, Iss 1, p 51 (2019)
Marine Drugs
Volume 17
Issue 1
ISSN: 1660-3397
Popis: Bisphosphonates (BPs) used for treating skeletal diseases can induce bisphosphonate-related osteonecrosis of the jaw (BRONJ). Despite much effort, effective remedies are yet to be established. In the present study, we investigated the feasibility of polydeoxyribonucleotide (PDRN) extracted from salmon sperm for the treatment of BRONJ, in a BRONJ-induced rat model. Compared with BRONJ-induced samples, PDRN-treated samples exhibited lower necrotic bone percentages and increased numbers of blood vessels and attached osteoclast production. Moreover, local administration of PDRN at a high concentration (8 mg/kg) remarkably resolved the osteonecrosis. Findings from this study suggest that local administration of PDRN at a specific concentration may be considered clinically for the management of BRONJ.
Databáze: OpenAIRE
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