Choroid plexus perfusion in sickle cell disease and moyamoya vasculopathy: Implications for glymphatic flow
| Autor: | Chelsea A Lee, Maria Garza, Manus J. Donahue, Matthew R. Fusco, Lori C. Jordan, Rohan V. Chitale, Sumit Pruthi, Paula Trujillo, Colin D. McKnight, Skylar E Johnson, L. Taylor Davis, Niral J Patel, Spencer L. Waddle, Daniel O. Claassen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Cell Anemia Sickle Cell 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Interstitial fluid Humans Medicine Vascular Diseases business.industry Original Articles medicine.anatomical_structure Neurology Choroid Plexus Female Glymphatic system Choroid plexus Neurology (clinical) Moyamoya Disease Cardiology and Cardiovascular Medicine business Glymphatic System Perfusion 030217 neurology & neurosurgery |
| Zdroj: | J Cereb Blood Flow Metab |
| ISSN: | 1559-7016 0271-678X |
| Popis: | Cerebrospinal fluid (CSF) and interstitial fluid exchange have been shown to increase following pharmacologically-manipulated increases in cerebral arterial pulsatility, consistent with arterial pulsatility improving CSF circulation along perivascular glymphatic pathways. The choroid plexus (CP) complexes produce CSF, and CP activity may provide a centralized indicator of perivascular flow. We tested the primary hypothesis that elevated cortical cerebral blood volume and flow, present in sickle cell disease (SCD), is associated with fractionally-reduced CP perfusion relative to healthy adults, and the supplementary hypothesis that reduced arterial patency, present in moyamoya vasculopathy, is associated with elevated fractional CP perfusion relative to healthy adults. Participants (n = 75) provided informed consent and were scanned using a 3-Tesla arterial-spin-labeling MRI sequence for CP and cerebral gray matter (GM) perfusion quantification. ANOVA was used to calculate differences in CP-to-GM perfusion ratios between groups, and regression analyses applied to evaluate the dependence of the CP-to-GM perfusion ratio on group after co-varying for age and sex. ANOVA yielded significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|