Infertility Caused by hCG Autoantibody
| Autor: | F. Amato, Robert J. Norman, C.A. Kirby, G. M. Warnes |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Infertility endocrine system medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Clinical Biochemistry Population Chorionic Gonadotropin Biochemistry Immunoglobulin G Endocrinology Antibody Specificity Internal medicine medicine Humans education Progesterone reproductive and urinary physiology Autoantibodies Cell Line Transformed Antiserum education.field_of_study biology Biochemistry (medical) Female infertility Autoantibody Leydig Cells Blood Physiological Phenomena medicine.disease Recombinant Proteins Titer biology.protein Female Antibody Infertility Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 87:993-997 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.87.3.8334 |
| Popis: | An anti-hCG autoantibody was found in a patient with a 9-yr history of secondary infertility. Although the patient had regular menstrual cycles, had conceived spontaneously, and had good hormonal and follicular responses to gonadotropic stimulation regimens during the in vitro fertilization work-up, she presented with apparent recurrent pregnancy loss associated with prolonged raised hCG levels. Initially the presence of a high mol wt hCG complex was demonstrated in the serum by gel chromatography. The binding of [(125)I]recombinant hCG to a serum sample and subsequently to the affinity-purified IgG from the same sample revealed the presence of an hCG antibody. The antiserum was shown to be specific, with a low affinity (K(a), 1.4 x 10(6) liters/mol), but a high capacity (418 nmol/liter), for hCG. Cross-reaction with recombinant human FSH, recombinant human LH, hCG alpha, and hCG beta were low ( |
| Databáze: | OpenAIRE |
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