Effect of Circulating Somatostatin on Exocrine Pancreatic Secretion in Conscious Dogs
| Autor: | Christoph Beglinger, Marie-Madeleine Loubatières-Mariani, Erich Kohler, Gérard Ribes, Klaus Gyr, Ulrich Grötzinger |
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| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Radioimmunoassay Peptide hormone Sincalide Dogs Endocrinology Pancreatic Juice Internal medicine Internal Medicine medicine Animals Secretion Pancreas Hepatology biology Chemistry Fissipedia Proteins biology.organism_classification Bicarbonates medicine.anatomical_structure Postprandial Somatostatin Research Design hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Pancreas. 1:455-459 |
| ISSN: | 0885-3177 |
| DOI: | 10.1097/00006676-198609000-00011 |
| Popis: | We determined the effects of exogenous somatostatin-14 (100 and 200 ng/kg/h; mimicking postprandial somatostatin concentrations) on pancreatic responses to a background infusion of secretion in combination with graded doses of CCK-8 in conscious dogs with chronic gastric and duodenal fistulas. The lower dose of somatostatin-14 (S-14), which produced S-14 plasma levels lower than measured after a meal, did not change basal or stimulated pancreatic secretion. The upper dose of S-14, which produced plasma S-14 concentrations slightly above the postprandial range, caused inhibition of pancreatic fluid and protein secretion to low doses of CCK-8 (p less than 0.05). The inhibition was surmountable with higher doses of CCK-8. We interpret these data as indicating that circulating S-14 is not an important hormonal regulator of exocrine pancreatic secretion. |
| Databáze: | OpenAIRE |
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