Scavenging Effect of Various Extracts of the Gymnema sylvestre R. Br. and Antioxidant Activity of the Isolated Triterpenes
| Autor: | Cinzia Di Marino, Valeria Romanucci, Piero Porcaro, Anna De Marco |
|---|---|
| Přispěvatelé: | Romanucci, Valeria, Piero, Porcaro, DI MARINO, Cinzia, DE MARCO, Anna |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
herbal drug
antioxidant Antioxidant medicine.medical_treatment Plant Science 01 natural sciences Terpene lcsh:Chemistry lcsh:QD241-441 03 medical and health sciences 0302 clinical medicine gymnemic acids lcsh:Organic chemistry lcsh:Botany Drug Discovery DCFH-DA assay medicine Scavenging Pharmacology Traditional medicine biology 010405 organic chemistry Chemistry Organic Chemistry Gymnema sylvestre biology.organism_classification 0104 chemical sciences lcsh:QK1-989 antioxidants lcsh:QD1-999 gymnemic acid 030220 oncology & carcinogenesis |
| Zdroj: | Records of Natural Products, Vol 12, Iss 1, Pp 53-63 (2018) |
| ISSN: | 1307-6167 |
| Popis: | Gymnema sylvestre has been used in Asian traditional medicine for its anti-microbial, anti-hypercholesterolemic, hepatoprotective and sweet suppressing properties and activities. G. sylvestre has also been used extensively in chewing gum, as a health food for preventing obesity and diabetes, and as a tea. This study has evaluated the total phenolic content and antioxidant activity of the aqueous and organic G. sylvestre extracts and their sub-fractions for the initial characterization of the biological properties of the isolated compounds. An in vivo cell model was used to calculate the concentration inhibiting cell growth by 50% and the ability to exert antioxidant activity. All compounds inhibit cell growth in a dose-dependent manner, with an IC 50 value ranging between 29 and 1462 μM. The effects on intracellular ROS levels are extremely variable, but it is of interest that some of the compounds appear to display an antioxidant effect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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