Blockers of Nicotinic Acetylcholine Receptors Delay Tumor Growth and Increase Antitumor Activity of Mouse Splenocytes

Autor:	Tatjana Balashevich, Tatsiana L. Yanchanka, V. I. Tsetlin, Yu. N. Utkin, E. A. Tamashionik, T. I. Terpinskaya, Alexey V. Osipov
Rok vydání:	2020
Předmět:	alpha7 Nicotinic Acetylcholine Receptor Carcinogenesis Cell Survival Biophysics Antineoplastic Agents Nicotinic Antagonists Receptors Nicotinic Pharmacology medicine.disease_cause Biochemistry Mice 03 medical and health sciences In vivo medicine Splenocyte Animals Cytotoxic T cell Carcinoma Ehrlich Tumor Cell Proliferation 030304 developmental biology Acetylcholine receptor 0303 health sciences Chemistry 030302 biochemistry & molecular biology General Chemistry General Medicine In vitro Blockade Nicotinic agonist Conotoxins Neoplasm Transplantation Spleen
Zdroj:	Doklady Biochemistry and Biophysics. 491:89-92
ISSN:	1608-3091 1607-6729
DOI:	10.1134/s1607672920020143
Popis:	Blockade of α6, α3β2, α9α10, and α7 subtypes of nicotinic acetylcholine receptors slows tumor growth in vivo, increases cytotoxic activity of splenocytes from tumor-bearing mice, and, to some extent, reduces the viability of Ehrlich carcinoma cells in vitro. These data indicate that nicotinic acetylcholine receptors are involved in oncogenesis, affecting the survival of tumor cells, inter alia, via modulation of the antitumor immunity.
Databáze:	OpenAIRE
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