Prognosis factors in the treatment of bisphosphonate-related osteonecrosis of the jaw - Prognostic factors in the treatment of BRONJ
| Autor: | Sho Mitsugi, Noriaki Yamamoto, Hiroyasu Kiyomiya, Kenkou Tanaka, Ikuya Miyamoto, Yoshihiro Kataoka, Kensuke Yamauchi, Shinnosuke Nogami, Daigo Yoshiga, Tetsu Takahashi, Ikuo Nakamichi, Takeshi Kaneuji, Yoshihiro Yamashita, Takuma Sakurai |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Side effect business.industry Medical record medicine.medical_treatment Research Retrospective cohort study Odontología Bisphosphonate medicine.disease CIENCIAS MÉDICAS [UNESCO] Ciencias de la salud Surgery N-terminal telopeptide Internal medicine UNESCO::CIENCIAS MÉDICAS Medicine Medical history Oral Surgery business Osteonecrosis of the jaw General Dentistry Progressive disease |
| Zdroj: | Yoshiga, Daigo ; Nakamichi, Ikuo ; Yamashita, Yoshihiro ; Yamamoto, Noriaki ; Yamauchi, Kensuke ; Nogami, Shinnosuke ; Kaneuji, Takeshi ; Mitsugi, Sho ; Tanaka, K. ; Kataoka, Yoshihiro ; Sakurai, Takuma ; Kiyomiya, Hiroyasu ; Miyamoto, Ikuya ; Takahashi, Tetsu. Prognosis factors in the treatment of bisphosphonate-related osteonecrosis of the jaw-Prognostic factors in the treatment of BRONJ-. En: Journal of Clinical and Experimental Dentistry, 2014, Vol. 6, No. 1: 22-28 Journal of Clinical and Experimental Dentistry RODERIC. Repositorio Institucional de la Universitat de Valéncia instname |
| Popis: | Objectives: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a relatively rare but serious side effect of bisphosphonate (BP)-based treatments. This retrospective study aimed to investigate the risk factors and predictive markers in cases where patients were refractory to a recommended conservative treatment offered in our hospital. Patients and Methods: This single-center study collated the medical records of all patients treated for BRONJ between 2004 and 2011. A complete medical history, including detailed questionnaires, was collected for all patients, focusing on identifying underlying risk factors, clinical features, location and bone marker levels of BRONJ. Results: The mean BRONJ remission rate was 57.6%, and the median duration of remission was seven months. Eighteen patients (34.6%) had persistent or progressive disease with a recommended conservative treatment for BRONJ. Notably, urinary cross-linked N-terminal telopeptide of type 1 collagen (NTX) levels in those resistant to conservative treatment tended to be lower than in patients that healed well. Conclusions: We confirm that a significant proportion of BRONJ sufferers are refractory to a recommended conservative treatment and find that anticancer drugs, periodontal disease, the level of bone exposure and the dosage of intravenous BPs (e.g. zoledronate) represent specific risk factors in BRONJ that may determine the success of a recommended conservative treatment. Additionally, the NTX levels might be able to be a prognostic factor for the conservative treatment of BRONJ; additional research is necessary. Key words:Bisphosphonate, osteonecrosis, jaw, prognostic, retrospective. |
| Databáze: | OpenAIRE |
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