Influence of polymorphisms in VEGF, ACE, TNF and GST genes on the susceptibility to retinopathy of prematurity among Chinese infants
| Autor: | Yong-Xia Zhao, Tong Qiao, Xiao-Jun Lei |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
oxidation Inflammation Disease Gastroenterology 03 medical and health sciences 0302 clinical medicine vascularization lcsh:Ophthalmology Internal medicine Genotype medicine retinopathy of prematurity Allele Gene business.industry Retinopathy of prematurity medicine.disease Ophthalmology Low birth weight inflammation lcsh:RE1-994 030221 ophthalmology & optometry Tumor necrosis factor alpha medicine.symptom polymorphisms business 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Ophthalmology, Vol 11, Iss 9, Pp 1451-1457 (2018) |
| ISSN: | 2227-4898 2222-3959 |
| Popis: | AIM: To investigate common polymorphisms in VEGF, ACE, TNF and GST genes with retinopathy of prematurity (ROP) risk among Chinese infants. METHODS: Nine polymorphisms in the above genes were genotyped on 724 advanced cases of ROP and 878 prematurely-born infants of low birth weight who were without any ophthalmologic disease. The frequencies of the polymorphisms were compared between cases and controls to identify the association present, if any. RESULTS: Of the nine polymorphisms, only two showed significant associations: ACE insertion deletion (ID) polymorphism (P=0.031) and TNF -308G/A polymorphism (P |
| Databáze: | OpenAIRE |
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