Diffusion-weighted imaging versus dynamic contrast-enhanced imaging for pre-operative diagnosis of deep myometrial invasion in endometrial cancer: A meta-analysis
| Autor: | Cher Heng Tan, Jeffrey Jen Hui Low, Li Jen Wang, Nicole Kessa Wee, Yi Ju Tseng |
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| Rok vydání: | 2021 |
| Předmět: |
Receiver operating characteristic
medicine.diagnostic_test business.industry Endometrial cancer Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Sensitivity and Specificity Pre operative Confidence interval Endometrial Neoplasms Dynamic contrast Diffusion Magnetic Resonance Imaging ROC Curve Meta-analysis medicine Humans Radiology Nuclear Medicine and imaging Female Nuclear medicine business Diffusion MRI |
| Zdroj: | Clinical imaging. 80 |
| ISSN: | 1873-4499 |
| Popis: | Purpose This study investigates the differences in diagnostic performance between diffuse-weighted imaging (DWI) and dynamic contrast-enhanced imaging (DCE), either alone or in combination with T2-weighted imaging (T2WI), for diagnosing deep myometrial invasion (dMI) of endometrial cancers (EC). Methods We performed a comprehensive search for published studies comparing DWI and DCE for preoperatively diagnosing dMI of EC. The overall diagnostic accuracy of each test was calculated using the areas under the summary receiver operating characteristic curves (AUCs). The sensitivities and specificities were compared using bivariate meta-regression. Results Pooled analysis of nineteen studies with 961 patients (main group) showed that DWI had a larger AUC (0.943, 95% confidence interval (CI) = 0.921–0.967) than DCE (0.922, 95% CI = 0.893–0.953). For the subgroup comprising 7 studies, DWI combined with T2WI and DCE combined with T2WI showed AUCs of 0.959 (95% CI, 0.932–0.986) and 0.929 (95% CI, 0.847–1.000), respectively. None of the differences in AUCs were statistically significant. All comparisons of the sensitivities and specificities of the main group and subgroup also showed no significant differences. Conclusion This meta-analysis found no significant difference in diagnostic performance between DWI and DCE for diagnosis of dMI in EC. DWI may be preferred for its ease of use in clinical practice. |
| Databáze: | OpenAIRE |
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