The Influence of Experimental Hypo- and Hyperthyroidism on the Effects of Nostal®, Thiopental Sodium, and Hexobarbital Sodium in the Adult Albino Rat*
| Autor: | Marvin H. Malone, Ira W.M. Hillyard, Harald G.O. Holck |
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| Rok vydání: | 1954 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases medicine.medical_treatment Hexobarbital Hyperthyroidism Median lethal dose Hexobarbital Sodium Hypothyroidism Internal medicine medicine Animals Thiopental Volume concentration Thiopental Sodium business.industry Incidence (epidemiology) Sodium Thyroidectomy Rats Endocrinology Barbiturates Thyroglobulin Propylthiouracil business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of the American Pharmaceutical Association (Scientific ed.). 43:276-282 |
| ISSN: | 0095-9553 |
| DOI: | 10.1002/jps.3030430508 |
| Popis: | Hypothyroidism produced by either feeding suitable concentrations of propylthiouracil, or by thyroidectomy, greatly increased the average recovery time of both male and female adult albino rats to Nostal®, thiopental sodium., and hexobarbital sodium. Thyroidectomy in male rats apreciably increased the incidence of acute deaths following Nostal®. The LD 50 of propylthiouracil injected intraperitoneally in a 5 per cent acacia suspension is 342 mg./Kg. No tolerance was built up to propylthiouracil when low concentrations were fed in the diet for two weeks. Intra-peritoneal injection of propylthiouracil in acacia suspension one hour prior to Nostal® had no effect on recovery time or incidence of acute death. Delayed deaths occurred sooner. Hyperthyroidism produced by feeding effective concentrations of either thyroglobulin or thyroxin caused no consistent shortening of the average recovery time from Nostal® and did not influence the incidence of either acute or delayed death. |
| Databáze: | OpenAIRE |
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