Trends in management and outcome of patients with non-ST elevation acute coronary syndromes and peripheral arterial disease
Autor: | Leonardo De Luca, Andrea Di Lenarda, Gianni Casella, Michele Massimo Gulizia, Leonardo Bolognese, Giuseppe Di Pasquale, Zoran Olivari, Alessandro Boccanelli, Lucio Gonzini, Stefano De Servi, Stefano Savonitto, Antonio Di Chiara, Francesco Chiarella |
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Rok vydání: | 2019 |
Předmět: |
Male
Change over time medicine.medical_specialty Arterial disease 030204 cardiovascular system & hematology Coronary Angiography Risk Assessment Electrocardiography Peripheral Arterial Disease 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Risk Factors Internal medicine Epidemiology Internal Medicine medicine Humans Hospital Mortality Registries 030212 general & internal medicine Acute Coronary Syndrome Aged Aged 80 and over business.industry ST elevation Middle Aged Peripheral Italy Baseline characteristics Multivariate Analysis Female business |
Zdroj: | European Journal of Internal Medicine. 59:70-76 |
ISSN: | 0953-6205 |
DOI: | 10.1016/j.ejim.2018.08.010 |
Popis: | Patients with non ST-segment elevation acute coronary syndromes (NSTE-ACS) and peripheral arterial disease (PAD) present a worse prognosis compared to those without PAD. We sought to describe contemporary trends of in-hospital management and outcome of patients admitted for NSTE-ACS with associated PAD.We analyzed data from 6 Italian nationwide registries, conducted between 2001 and 2014, including consecutive NSTE-ACS patients.Out of 15,867 patients with NSTE-ACS enrolled in the 6 registries, 2226 (14.0%) had a history of PAD. As compared to non-PAD patients, those with PAD had significantly more risk factors and comorbidities (all p 0.0001) that increased over time. Patients with PAD underwent less frequently coronary angiography (72.0% vs 79.2%, p 0.0001) and percutaneous coronary intervention (PCI, 42.9% vs 51.8%, p 0.0001), compared to patients without PAD. Over the years, a progressive and similar increase occurred in the rates of invasive procedures both in patients with and without PAD (both p for trend0.0001). The crude in-hospital mortality rate did not significantly change over time (p for trend = 0.83). However, as compared to 2001, the risk of death was significantly lower in all other studies performed at different times, after adjustment for multiple comorbidities.. At multivariable analysis, PAD on admission was an independent predictor of in-hospital mortality [odds ratio (OR): 1.75; 95% confidence intervals (CI): 1.35-2.27; p 0.0001].Over the 14 years of observation, patients with PAD and NSTE-ACS exhibited worsening baseline characteristics and a progressive increase in invasive procedures. Whereas crude in-hospital mortality did not change over time, we observed a significant reduction in comorbidity-adjusted mortality, as compared to 2001. |
Databáze: | OpenAIRE |
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