Lymphocyte Subsets in Muscle Biopsies of Human T-Lymphotropic Virus Type I Carriers with Polymyositis
| Autor: | Mitsuhiro Osame, Hidetoshi Fukunaga, Itsuro Higuchi, Shuji Izumo, Toshiharu Ijichi |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Muscle tissue Pathology medicine.medical_specialty Human T-lymphotropic virus Polymyositis Immunophenotyping Antigen Antigens CD Internal Medicine medicine Humans Antigens Viral Aged Human T-lymphotropic virus 1 Immunity Cellular Perimysium biology business.industry Macrophages Muscles Skeletal muscle General Medicine Middle Aged Endomysium biology.organism_classification medicine.disease Lymphocyte Subsets medicine.anatomical_structure Immunology Female business |
| Zdroj: | Internal Medicine. 31:973-977 |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | Recent epidemiologic studies have shown that human T-lymphotropic virus type I (HTLV-I) is associated with polymyositis. To clarify the histological features of HTLV-I positive polymyositis, we studied muscle tissue from two groups of patients with polymyositis, those seropositive for HTLV-I (5 patients) and those seronegative (5 patients). We examined the lymphocyte subsets in muscle biopsies using monoclonal antibodies. In the endomysium, a variable number of T-lymphocytes and macrophages and a smaller proportion of B-lymphocytes were found in both groups. In both HTLV-I positive and negative patients a variable number of T-lymphocytes and macrophages, with a smaller number of B-lymphocytes, were found in the perimysium. As a whole, the T-lymphocytes were predominantly of the helper/inducer phenotype in both groups. We failed to find any specific phenotype distribution among T-cells infiltrating the muscle of HTLV-I carriers with polymyositis. |
| Databáze: | OpenAIRE |
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