Sensitive determination of vincristine in plasma of children with leukaemia using vortex-assisted dispersive liquid–liquid microextraction based on hydrophobic deep eutectic solvent

Autor: Mohammad Reza Golpayegani, Reza Akramipour, Simin Gheini, Mazyar Vakili Amini, Farshad Fattahi, Ali Mohebbi, Nazir Fattahi
Rok vydání: 2022
Předmět:
Zdroj: RSC Advances. 12:3611-3617
ISSN: 2046-2069
DOI: 10.1039/d1ra07981f
Popis: Vincristine has a wide spectrum of clinical activity and is currently used in the treatment of leukemia. Despite its high therapeutic properties, vincristine has common side effects. Accordingly, it is desirable to determine vincristine in plasma for the use of the drug with strict monitoring. In the present research, for the first time a hydrophobic deep eutectic solvent (DES) composed of methyltrioctylammonium chloride (MTOAC) and
Databáze: OpenAIRE