A cell type-specific cortico-subcortical brain circuit for investigatory and novelty-seeking behavior
| Autor: | Janou H. W. Houba, Maryam Darbanfouladi, Mehran Ahmadlou, Jacqueline F. M. van Vierbergen, Maria Giannouli, Maryam Yasamin Shirazi, Geoffrey-Alexander Gimenez, Julia Dziubek, J. Alexander Heimel, Fred de Winter, Christiaan van Weeghel, Mejdy Kacem |
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| Přispěvatelé: | Netherlands Institute for Neuroscience (NIN) |
| Rok vydání: | 2020 |
| Předmět: |
Male
Infralimbic cortex Social Interaction Neural Inhibition Prefrontal Cortex Optogenetics Biology Inhibitory postsynaptic potential Periaqueductal gray Arousal Mice Tachykinins Neural Pathways medicine Animals Periaqueductal Gray Zona Incerta gamma-Aminobutyric Acid Cerebral Cortex Neurons Motivation Multidisciplinary Behavior Animal Axons medicine.anatomical_structure Excitatory postsynaptic potential Exploratory Behavior Zona incerta Female Neuroscience |
| Zdroj: | Science, 372:eabe9681. American Association for the Advancement of Science (AAAS) |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | A brain circuit that drives and gates curiosity Curiosity is what drives organisms to investigate each other and their environment. It is considered by many to be as intrinsic as hunger and thirst, but the neurobiological mechanisms behind curiosity have remained elusive. In mice, Ahmadlou et al. found that a specific population of genetically identified γ-aminobutyric acid (GABA)—ergic neurons in a brain region called the zona incerta receive excitatory input in the form of novelty and/or arousal information from the prelimbic cortex, and these neurons send inhibitory projections to the periaqueductal gray region (see the Perspective by Farahbakhsh and Siciliano). This circuitry is necessary for the exploration of new objects and conspecifics. Science , this issue p. eabe9681 ; see also p. 684 |
| Databáze: | OpenAIRE |
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