Evolution of the Genome 3D Organization: Comparison of Fused and Segregated Globin Gene Clusters
| Autor: | Yegor S. Vassetzky, Olga V. Iarovaia, Sergey V. Ulianov, Ilya M. Flyamer, Sergey V. Razin, Alexey A. Gavrilov, E. S. Ioudinkova, Aleksandra A. Galitsyna, Evgeny S. Gerasimov, Konstantin V Dolgushin, N. V. Petrova, A. P. Kovina, E. S. Gushchanskaya, Alexey A. Penin |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
animal structures Danio Molecular Conformation Locus (genetics) beta-Globins Genome Chromosomes Birds Evolution Molecular 03 medical and health sciences 0302 clinical medicine alpha-Globins Genetics Animals Globin Enhancer Molecular Biology Gene Ecology Evolution Behavior and Systematics Zebrafish Synteny Mammals biology fungi biology.organism_classification Biological Evolution Chromatin Globins 030104 developmental biology Multigene Family 030217 neurology & neurosurgery |
| Zdroj: | Molecular biology and evolution. 34(6) |
| ISSN: | 1537-1719 |
| Popis: | The genomes are folded in a complex three-dimensional (3D) structure. Some features of this organization are common for all eukaryotes, but little is known about its evolution. Here, we have studied the 3D organization and regulation of zebrafish globin gene domain and compared its organization and regulation with those of other vertebrate species. In birds and mammals, the α- and β-globin genes are segregated into separate clusters located on different chromosomes and organized into chromatin domains of different types, whereas in cold-blooded vertebrates, including Danio rerio, α- and β-globin genes are organized into common clusters. The major globin gene locus of Danio rerio is of particular interest as it is located in a genomic area that is syntenic in vertebrates and is controlled by a conserved enhancer. We have found that the major globin gene locus of Danio rerio is structurally and functionally segregated into two spatially distinct subloci harboring either adult or embryo-larval globin genes. These subloci demonstrate different organization at the level of chromatin domains and different modes of spatial organization, which appears to be due to selective interaction of the upstream enhancer with the sublocus harboring globin genes of the adult type. These data are discussed in terms of evolution of linear and 3D organization of gene clusters in vertebrates. |
| Databáze: | OpenAIRE |
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