Whole-genome analysis of introgressive hybridization and characterization of the bovine legacy of Mongolian yaks
| Autor: | E. A. Gladyr, André Eggen, Aurélien Capitan, Alexander Graf, Stefan Krebs, Ingolf Russ, Garrett Hellenthal, Sophie Rothammer, Helmut Blum, Natalia A Zinovieva, Johanna Barbieri, Doris Seichter, Ivica Medugorac, Gottfried Brem, Cécile Grohs, Yondon Zagdsuren |
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| Přispěvatelé: | Chair of Animal Genetics and Husbandry, Ludwig-Maximilians-Universität München (LMU), Laboratory for Functional Genome Analysis, Gene Center, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Sum, Mongolian Jak Society, Center of Biotechnology and Molecular Diagnostics, L.K. Ernst Institute of Animal Husbandry, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Tierzuchtforschung e.V Munchen, AgriGenomics, Illumina, Genetics Institute, Faculty of Life Sciences, University College London (UCL), Institute of Animal Breeding and Genetics, Department for Biomedical Sciences, University of Veterinary Medicine [Vienna] (Vetmeduni), Allice, Hornout Apisgene, Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT] |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Genotype [SDV]Life Sciences [q-bio] Population genetics Introgression Genomics interspecific hybridization Biology Breeding Genome Polymorphism Single Nucleotide 03 medical and health sciences Genetics Animals Hybrid yak 2. Zero hunger Haplotype 0402 animal and dairy science 04 agricultural and veterinary sciences 15. Life on land 040201 dairy & animal science SNP genotyping séquence du génome 030104 developmental biology Phenotype Backcrossing hybridation interspécifique Hybridization Genetic Cattle Female Genome-Wide Association Study |
| Zdroj: | Nature Genetics Nature Genetics, Nature Publishing Group, 2017, 49 (3), pp.470-475. ⟨10.1038/ng.3775⟩ |
| ISSN: | 1061-4036 1546-1718 |
| DOI: | 10.1038/ng.3775⟩ |
| Popis: | The yak is remarkable for its adaptation to high altitude and occupies a central place in the economies of the mountainous regions of Asia. At lower elevations, it is common to hybridize yaks with cattle to combine the yak's hardiness with the productivity of cattle. Hybrid males are sterile, however, preventing the establishment of stable hybrid populations, but not a limited introgression after backcrossing several generations of female hybrids to male yaks. Here we inferred bovine haplotypes in the genomes of 76 Mongolian yaks using high-density SNP genotyping and whole-genome sequencing. These yaks inherited ∼1.3% of their genome from bovine ancestors after nearly continuous admixture over at least the last 1,500 years. The introgressed regions are enriched in genes involved in nervous system development and function, and particularly in glutamate metabolism and neurotransmission. We also identified a novel mutation associated with a polled (hornless) phenotype originating from Mongolian Turano cattle. Our results suggest that introgressive hybridization contributed to the improvement of yak management and breeding. |
| Databáze: | OpenAIRE |
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