Development of Intramammary Drug Delivery Systems: Novel In Vitro Release Method
| Autor: | Kiro R. Petrovski, Darren J. Trott, Sanjay Garg, Wen Wang, Stephen W. Page, Yunmei Song, Patricia Eats |
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| Přispěvatelé: | Garg, Sanjay, Wang, Wen, Song, Yunmei, Eats, Patricia, Trott, Darren J, Page, Stephen W, Petrovski, Kiro R |
| Rok vydání: | 2016 |
| Předmět: |
Lasalocid
Pharmaceutical Science Release model vitro models 030226 pharmacology & pharmacy Dialysis tubing 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Delivery Systems Mammary Glands Animal In vivo dissolutionin Animals in vitro/in vivo correlations solid dispersion Chromatography business.industry Chemistry solubility 0402 animal and dairy science 04 agricultural and veterinary sciences 040201 dairy & animal science In vitro Biotechnology Cell system Anti-Bacterial Agents Drug Liberation Delayed-Action Preparations Drug delivery Cattle Female business mathematical model After treatment |
| Zdroj: | Journal of pharmaceutical sciences. 106(3) |
| ISSN: | 1520-6017 |
| Popis: | The aim of this study was to develop an in vitro release model for intramammary drug delivery system (IMDS) evaluation. This study was the first to establish an in vitro-in vivo correlation with investigation of an IMDS containing lasalocid. Three different methods including the standard United States Pharmacopeia dissolution method with apparatus 2, a modified United States Pharmacopeia method using a dialysis bag, or a specifically designed enhancer cell system, were assessed for the release study. Full cream milk and water were selected as the release media. In vivo evaluation was carried out by administering lasalocid IMDS into the udder of lactating Holstein dairy cows. Milk samples were collected and analyzed at selected time points after treatment. Dissolution data were fitted to various kinetic models. The results indicated that the release rate of lasalocid from IMDS was controlled by factors other than diffusion, which could include the sedimentation of lasalocid to the interface and the wetting of lasalocid particles by water at the interface of oil in the formulation and release media. The results obtained in vivo and in vitro were consistent. The in vitro assessment supports formulation design for early stage development and potentially for in vivo performance analysis. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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