Influence and significance of certain prognostic factors on survival in breast cancer
| Autor: | John Hanson, V.P. Zuck, A. H. G. Paterson, Alan W. Lees, Olga Szafran |
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| Rok vydání: | 1982 |
| Předmět: |
Oncology
medicine.medical_specialty Prognostic factor Time Factors Breast Neoplasms Disease Breast cancer Biological property Internal medicine medicine Axillary nodes Humans Oestrogen receptor Neoplasm Metastasis Stage (cooking) Pathological Neoplasm Staging business.industry Prognosis medicine.disease Receptors Estrogen Axilla Female Lymph Nodes business |
| Zdroj: | European Journal of Cancer and Clinical Oncology. 18:937-943 |
| ISSN: | 0277-5379 |
| DOI: | 10.1016/0277-5379(82)90241-3 |
| Popis: | Prognostic factors documented at presentation of patients with breast cancer are usually studied by dividing all patients diagnosed as having breast cancer into prognostic factor subgroups and analysing their respective survivals. This method assumes that the biological nature of the disease in each group is similar, an assumption which may not be valid. In order to examine these presenting prognostic factors as they apply to patients with disease of proven distant metastatic potential, we analysed their influence on the survival of 896 patients who presented with breast cancer at our hospital and developed distant metastases during 1971–1980 . We also analysed, in the traditional way, these prognostic factors as they affected the survival from primary treatment of 3084 patients who presented with breast cancer at our hospital during 1971–1980 . As has been reported many times previously, survival from primary treatment of all patients with breast cancer was influenced by clinical stage at presentation, pathological axillary node status and oestrogen receptor level of the primary tumour. This influence was also seen in the distant metastasis-free period when only patients who developed distant metastases were analysed. In contrast, of the three prognostic factors studied, only the presenting level of oestrogen receptor was shown to influence the course of the disease after the development of first distant metastasis. These results suggest that the oestrogen receptor level of the primary tumour is a biological prognostic factor exerting an influence throughout the course of the disease, whereas clinical stage and pathological axillary node status reflect more the age of the tumour than its intrinsic biological properties. Our study provides support for basing adjuvant therapeutic protocols as much on the oestrogen receptor level of the primary tumour as on the presence or absence of disease in the axillary nodes. |
| Databáze: | OpenAIRE |
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