INFLUENCE OF ISLET TRANSPORTATION ON PANCREATIC ISLET ALLOTRANSPLANTATION IN TYPE 1 DIABETIC PATIENTS WITHIN THE SWISS-FRENCH GRAGIL NETWORK
| Autor: | Laurence Kessler, Edith Renoult, Pierre-Yves Benhamou, François Bayle, Laure Milliat-Guittard, Lionel Badet, Charles Thivolet, Jose Oberholzer, Cyrille Colin, Pascal Alain Robert Bucher, Alfred Penfornis, Philippe Morel, Jean Marcel Brun, Thierry Berney, Gérard Rifle, Catherine Atlan |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Oncology endocrine system medicine.medical_specialty Time Factors Tissue and Organ Procurement endocrine system diseases Tissue and Organ Procurement/methods medicine.medical_treatment Islets of Langerhans Transplantation Transportation Hemoglobin A Glycosylated/metabolism Internal medicine Immunopathology medicine Humans Glycated Hemoglobin Autoimmune disease Transplantation Type 1 diabetes geography geography.geographical_feature_category ddc:617 C-Peptide business.industry Graft Survival Islets of Langerhans Transplantation/methods/physiology Creatinine/blood Middle Aged medicine.disease Islet Diabetes Mellitus Type 1 Endocrinology Diabetes Mellitus Type 1/surgery Creatinine C-Peptide/blood Female France business Switzerland Allotransplantation |
| Zdroj: | Transplantation, Vol. 77, No 8 (2004) pp. 1301-4 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/01.tp.0000122223.79315.5d |
| Popis: | The influence of islet transportation on pancreatic islet allotransplantation in type 1 diabetic patients was evaluated within the GRAGIL network.From December 2001 to April 2003, 16 human pancreatic islet transplants were performed in 9 type 1 diabetic patients with an established kidney graft (functioning for at least 6 months) in four centers of the GRAGIL network. Islet isolation was performed in a core laboratory in Geneva, and the islet preparations were shipped by ambulance to each center for transplantation. One month after transplantation, the efficiency of the graft was assessed according to islet transportation time (ITT): ITT less than 2 hours (group 1, n=5), and ITT greater than 4.5 hours (group 2, n=4, mediant 5 hours).Primary graft dysfunction was observed in one patient in group 1 after one month. Two patients became insulin independent in groups 1 and 2. All other patients in both groups had a plasma C-peptide level greater than 0.5 ng/ml. The HbA1c level and the exogenous insulin needs decreased in both groups.ITT does not seem to influence the efficiency of pancreatic islet allotransplantation in type 1 diabetic patients. These results emphasize the scope for multicenter networks such as the GRAGIL group. |
| Databáze: | OpenAIRE |
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