E2F-6, a member of the E2F family that can behave as a transcriptional repressor
| Autor: | Jacqueline A. Lees, Brian Fairchild, Raluca Verona, Nancy Andon, Jeffrey M. Trimarchi, Kenneth H. Moberg |
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| Rok vydání: | 1998 |
| Předmět: |
DNA
Complementary Response element Molecular Sequence Data E2F6 Transcription Factor E-box Transcription coregulator Biology Retinoblastoma Protein Mice Antibody Specificity Genes Reporter Animals Humans Tissue Distribution Amino Acid Sequence Cloning Molecular E2F Genetics Multidisciplinary General transcription factor Sequence Homology Amino Acid ETS transcription factor family Promoter Biological Sciences Repressor Proteins stomatognathic diseases Gene Expression Regulation Multigene Family embryonic structures biological phenomena cell phenomena and immunity E2F Transcription Factors Dimerization Protein Binding Transcription Factors |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 95(6) |
| ISSN: | 0027-8424 |
| Popis: | The E2F family of proteins is required to establish the correct cell-cycle-dependent transcription of genes that direct the process of cell division. All previously identified E2F proteins can act in a similar manner; depending on whether or not they are associated with the cell cycle inhibitors the retinoblastoma protein (pRB), p107, or p130, they can either repress or activate the transcription of E2F-responsive genes. We now report the cloning and characterization of another E2F family member, E2F-6, whose structure is reminiscent of the dominant inhibitors of other transcription factor families. The dimerization and DNA binding properties of E2F-6 are similar to those of the other E2F family members. However, it is not regulated by pRB, p107, or p130, and it is unable to activate transcription. Instead, it can act to repress the transcription of E2F responsive genes by countering the activity of the other E2F complexes via a pRB-, p107-, or p130-independent mechanism. |
| Databáze: | OpenAIRE |
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