Web-based thyroid imaging reporting and data system: Malignancy risk of atypia of undetermined significance or follicular lesion of undetermined significance thyroid nodules calculated by a combination of ultrasonography features and biopsy results
| Autor: | Tae Yong Kim, Jung Hwan Baek, Won-Hong Lee, Young Jun Choi, Jeong Hyun Lee, Jung Hee Shin, Dong Eun Song, Seon-Ok Kim, Woo Hyun Shim, Ki-Wook Chung |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Thyroid nodules medicine.medical_specialty 030209 endocrinology & metabolism Malignancy Young Adult 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Biopsy medicine Atypia Data Systems Humans Thyroid Nodule Nuclear atypia Aged Retrospective Studies Ultrasonography Internet Receiver operating characteristic medicine.diagnostic_test business.industry Biopsy Needle Thyroid Ultrasound Middle Aged medicine.disease Radiology Information Systems medicine.anatomical_structure ROC Curve Otorhinolaryngology 030220 oncology & carcinogenesis Female Radiology business |
| Zdroj: | Head & Neck. 40:1917-1925 |
| ISSN: | 1043-3074 |
| DOI: | 10.1002/hed.25173 |
| Popis: | BACKGROUND The purpose of this study was to construct a web-based predictive model using ultrasound characteristics and subcategorized biopsy results for thyroid nodules of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) to stratify the risk of malignancy. METHODS Data included 672 thyroid nodules from 656 patients from a historical cohort. We analyzed ultrasound images of thyroid nodules and biopsy results according to nuclear atypia and architectural atypia. Multivariate logistic regression analysis was performed to predict whether nodules were diagnosed as malignant or benign. RESULTS The ultrasound features, including spiculated margin, marked hypoechogenicity, calcifications, biopsy results, and cytologic atypia, showed significant differences between groups. A 13-point risk scoring system was developed, and the area under the curve (AUC) of the receiver operating characteristic (ROC) curve of the development and validation sets were 0.837 and 0.830, respectively (http://www.gap.kr/thyroidnodule_b3.php). CONCLUSION We devised a web-based predictive model using the combined information of ultrasound characteristics and biopsy results for AUS/FLUS thyroid nodules to stratify the malignant risk. |
| Databáze: | OpenAIRE |
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