Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation—Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF)
| Autor: | Nobuhiro Ikemura, Kenneth W. Mahaffey, Takehiro Kimura, Ikuko Ueda, Masahiro Suzuki, Hideo Mitamura, Makoto Akaishi, Jonathan P. Piccini, Keiichi Fukuda, Shun Kohsaka, Iwao Nakamura, John A. Spertus, Kojiro Tanimoto, Seiji Takatsuki, Taku Inohara |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Population Comorbidity Patient-Centred Medicine quality in health care 03 medical and health sciences 0302 clinical medicine Japan Quality of life adult cardiology Internal medicine Atrial Fibrillation Humans Medicine Patient Reported Outcome Measures Prospective Studies Registries 030212 general & internal medicine Prospective cohort study education Stroke pacing & electrophysiology Aged Fibrillation education.field_of_study Cohort Profile business.industry Vascular disease Anticoagulants Atrial fibrillation General Medicine Middle Aged medicine.disease Cohort Quality of Life Female medicine.symptom business Anti-Arrhythmia Agents 030217 neurology & neurosurgery |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| DOI: | 10.1136/bmjopen-2019-032746 |
| Popis: | PurposeBesides the high rates of morbidity and mortality, atrial fibrillation (AF) is also associated with impairment of quality-of-life (QOL). However, reports covering non-selected AF population within Asian countries remain scarce. The objective of the Keio interhospital Cardiovascular Studies-atrial fibrillation (KiCS-AF) registry is to clarify the baseline and QOL profiles of the AF patients at the time of initial referral to identify areas for improvement and country-specific gaps.ParticipantsThe KiCS-AF registry is a multicentre, prospective cohort study designed to specifically recruit AF patients newly referred to the 11 network hospitals within the Kanto area of Japan. The registry completed its enrolment in June 2018. All patients were requested to answer the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire both at baseline and 1 year, with planned clinical follow-up for 5 years. The registry also assessed individual treatment strategies including rate and rhythm control, stroke prophylaxis, and their impacts on patient-reported QOL.Findings to dateAs of December 2016, 2464 AF patients were registered; their mean age was 67.1 years (SD, 11.7), majority (69.7%; n=1717) were men and 49.2% presented with paroxysmal AF. The mean CHA2DS2-VASc (cardiac failure or dysfunction, hypertension, age ≥75 years, diabetes, stroke including vascular disease, age 65-74 years, and sex category [female]) score was 2.3 (SD, 1.6) and oral anticoagulant therapy was used for 88.6% of patients with CHA2DS2-VASc scores ≥2. The median AFEQT-overall summary score was 79.1 (IQR, 66.6–89.1). Roughly 50% had significantly impaired QOL (ie, AFEQT Future plansThe KiCS-AF allowed for extensive investigation of AF-related QOL in a non-selected population with long-term follow-up using a rigorously validated QOL assessment tool. Almost half of patients had impaired QOL at baseline. Further investigations aimed at providing care and improving patient-reported QOL are required. |
| Databáze: | OpenAIRE |
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