Evaluation of proposed staging systems for human papillomavirus‐related oropharyngeal squamous cell carcinoma
| Autor: | William H. Westra, Jeremy D. Richmon, Ian James Malm, Wayne M. Koch, Linda X. Yin, David W. Eisele, Caleb J. Fan, Harry Quon, David X. Li, Christine G. Gourin, Karen T. Pitman, Hyunseok Kang, Carole Fakhry |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Population Kaplan-Meier Estimate Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Stage (cooking) 030223 otorhinolaryngology education Papillomaviridae Lymph node Survival analysis Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies AJCC staging system education.field_of_study Squamous Cell Carcinoma of Head and Neck business.industry Papillomavirus Infections Reproducibility of Results Middle Aged Prognosis Regression Survival Rate Oropharyngeal Neoplasms medicine.anatomical_structure Head and Neck Neoplasms 030220 oncology & carcinogenesis Cohort Carcinoma Squamous Cell Female Lymph Nodes Akaike information criterion business Neck |
| Zdroj: | Cancer. 123:1768-1777 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/cncr.30512 |
| Popis: | BACKGROUND Patients with human papillomavirus (HPV)-related oropharyngeal cancer (OPC) have improved survival when compared with those with HPV-negative OPC. Unfortunately, the American Joint Committee on Cancer seventh edition (AJCC-7ed) staging system does not account for the prognostic advantage observed with HPV-positive OPC. The purpose of the current study was to validate and compare 2 recently proposed staging systems for HPV-positive OPC. METHODS Patients treated for HPV-positive OPC from 2005 to 2015 at Johns Hopkins Hospital (JHH) were included for analysis. The International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S) and The University of Texas MD Anderson Cancer Center (MDACC) staging systems were applied and survival was calculated using Kaplan-Meier methods. Cox proportional hazard regression was used to determine the relationship between stage of disease and survival. Models were compared using the Akaike information criterion (AIC). RESULTS A total of 435 patients were eligible for analysis. There was a dramatic shift in lymph node category and overall stage of disease when ICON-S and MDACC stage were applied to the JHH cohort. There was superior stratification of overall survival and progression-free survival by ICON-S stage. Both proposed models had an improved fit based on AIC scores (P |
| Databáze: | OpenAIRE |
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