Non-Invasive Diagnostic System Based on Light for Detecting Early-Stage Oral Cancer and High-Risk Precancerous Lesions-Potential for Dentistry
| Autor: | Seiko Tatehara, Kazuhito Satomura |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
Epithelial dysplasia medicine.medical_specialty Review autofluorescence lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine oral potentially malignancy disorders (OPMDs) Biopsy medicine protoporphyrin IX Oral mucosa Stage (cooking) oral epithelial dysplasia (OED) medicine.diagnostic_test business.industry photodynamic diagnosis (PDD) Non invasive Cancer 030206 dentistry Gold standard (test) oral cancer lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease chemiluminescence Autofluorescence stomatognathic diseases medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Radiology fluorescence business |
| Zdroj: | Cancers Cancers, Vol 12, Iss 3185, p 3185 (2020) |
| ISSN: | 2072-6694 |
| Popis: | Simple Summary The early detection of oral cancer and oral potentially malignant disorders can facilitate minimum intervention and subsequent improvements in prognosis and quality of life after treatment. Recently, several non-invasive adjunctive fluorescence-based detection systems have improved the accuracy of detection and diagnosis of oral cancer and oral potentially malignant disorders. This article summarizes current knowledge about fluorescence-based diagnostic methods and discusses their benefits and drawbacks from a clinical viewpoint. Abstract Oral health promotion and examinations have contributed to the early detection of oral cancer and oral potentially malignant disorders, leading to the adaptation of minimally invasive therapies and subsequent improvements in the prognosis/maintenance of the quality of life after treatments. However, the accurate detection of early-stage oral cancer and oral epithelial dysplasia is particularly difficult for conventional oral examinations because these lesions sometimes resemble benign lesions or healthy oral mucosa tissues. Although oral biopsy has been considered the gold standard for accurate diagnosis, it is deemed invasive for patients. For this reason, most clinicians are looking forward to the development of non-invasive diagnostic technologies to detect and distinguish between cancerous and benign lesions. To date, several non-invasive adjunctive fluorescence-based detection systems have improved the accuracy of the detection and diagnosis of oral mucosal lesions. Autofluorescence-based systems can detect lesions as a loss of autofluorescence through irradiation with blue-violet lights. Photodynamic diagnosis using 5-aminolevulinic acid (ALA-PDD) shows the presence of very early oral cancers and oral epithelial dysplasia as a red fluorescent area. In this article, currently used fluorescence-based diagnostic methods are introduced and discussed from a clinical point of view. |
| Databáze: | OpenAIRE |
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