Local and systemic effects of a silver nitrate coated indwelling pleural catheter in an animal model of pleurodesis
| Autor: | Alain Tremblay, Karen Sargis, Luke Zhang, David S. White, Craig E. Zook, Jennifer Hughes Hanks, Christine T. Kearney, Chris Hanks, Marcia E. Pereira |
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| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Silver Pleural effusion medicine.medical_treatment Clinical Biochemistry Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Catheters Indwelling Coated Materials Biocompatible White blood cell Internal medicine medicine Animals Tissue Distribution 030212 general & internal medicine Molecular Biology Pleurodesis business.industry medicine.disease Silver nitrate Catheter medicine.anatomical_structure 030228 respiratory system chemistry Toxicity Pleura Silver Nitrate Hemoglobin Indwelling pleural catheter business |
| Zdroj: | Experimental lung research. 43(9-10) |
| ISSN: | 1521-0499 |
| Popis: | Purpose/Aim of the study: This study assessed the safety and potential toxicity of a silver nitrate coated indwelling pleural catheter (SNCIPC) designed to create pleurodesis in a large animal model. MATERIALS AND METHODS Sixteen animals underwent insertion of either a SNCIPC or an uncoated silicone catheter. Half of the animals were sacrificed at day 7 and the others at day 30. Animal weight and assessment of well-being, pleural fluid and blood collection were performed at regular intervals. Pleurodesis was assessed at necropsy and histopathological examination of organs performed. RESULTS No mortality or significant clinical findings were observed throughout the experiment. SNCIPC treated animals had increased pleural fluid drainage overall (p |
| Databáze: | OpenAIRE |
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