Triclosan affects motor function in zebrafish larva by inhibiting ache and syn2a genes
| Autor: | Suman Abhishek, Narasimha Pullaguri, Anamika Bhargava, Yogesh Bhargava, Eerappa Rajakumara, Poonam Grover |
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| Rok vydání: | 2020 |
| Předmět: |
Nervous system
animal structures Environmental Engineering Aché Health Toxicology and Mutagenesis 0208 environmental biotechnology 02 engineering and technology 010501 environmental sciences Biology 01 natural sciences chemistry.chemical_compound medicine Environmental Chemistry Animals Humans Gene Zebrafish 0105 earth and related environmental sciences Public Health Environmental and Occupational Health General Medicine General Chemistry Human brain Motor neuron Antimicrobial Pollution Acetylcholinesterase language.human_language Triclosan 020801 environmental engineering Cell biology medicine.anatomical_structure chemistry Larva language Water Pollutants Chemical |
| Zdroj: | Chemosphere. 266 |
| ISSN: | 1879-1298 |
| Popis: | The widespread use of triclosan in personal care products as an antimicrobial agent is leading to its alarming tissue-bioaccumulation including human brain. However, knowledge of its potential effects on the vertebrate nervous system is still limited. Here, we hypothesized that sublethal triclosan concentrations are potent enough to alter motor neuron structure and function in zebrafish embryos exposed for prolonged duration. In this study, zebrafish embryos were used as vertebrate-animal model. Prolonged exposure (up to 4 days) of 0.6 mg/L (LC50, 96 h) and 0.3 mg/L ( |
| Databáze: | OpenAIRE |
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