Sauchinone inhibits the proliferation, migration and invasion of breast cancer cells by suppressing Akt-CREB-MMP13 signaling pathway
| Autor: | Nam Ji Sung, Na Hui Kim, Deok-Seon Ryu, Sin-Aye Park, Seokwon Shin, Hyung-Sun Youn |
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| Rok vydání: | 2021 |
| Předmět: |
MAPK/ERK pathway
Biophysics Breast Neoplasms Dioxoles CREB matrix metalloproteinase-13 Biochemistry Cell Movement Cell Line Tumor Matrix Metalloproteinase 13 Humans Benzopyrans Neoplasm Invasiveness Phosphorylation Cyclic AMP Response Element-Binding Protein Molecular Biology Protein kinase B Research Articles Cell Proliferation Cancer Sauchinone Breast cancer cells Gene Expression & Regulation biology Chemistry Pharmacology & Toxicology Cell migration Cell Biology Antineoplastic Agents Phytogenic Gene Expression Regulation Neoplastic Cell Cycle Growth & Proliferation Cancer cell Cell Migration Adhesion & Morphology biology.protein Cancer research Female Signal transduction Proto-Oncogene Proteins c-akt Signal Transduction Transforming growth factor |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 0144-8463 |
| Popis: | Sauchinone, a lignan isolated from Saururus chinenesis, is known to exhibit anti-inflammatory and anti-oxidant effects. Recently, sauchinone has been reported to inhibit the growth of various cancer cells, but its effects on breast cancer cells remain poorly understood. In the present study, we investigated the effects of sauchinone on the growth of breast cancer cells along with the underlying molecular mechanisms. Our results show that sauchinone treatment markedly inhibited the proliferation, migration, and invasion of breast cancer cells. Sauchinone reduced the phosphorylation of Akt, ERK, and CREB increased by transforming growth factor-β (TGF-β). In particular, sauchinone treatment suppressed the expression of matrix metalloproteinase (MMP)-13 (MMP13) by regulating the Akt-CREB signaling pathway. Sauchinone was less effective in inhibiting cell migration in Mmp13-knockdown cells than in control cells, suggesting that MMP13 may be a novel target for sauchinone. Our study suggests that sauchinone inhibits the growth of breast cancer cells by attenuating the Akt-CREB-MMP13 pathway. In addition, the targeted inhibition of MMP13 by sauchinone represents a promising approach for the treatment of breast cancer. |
| Databáze: | OpenAIRE |
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