Effect of ingenol mebutate on actinic keratosis in a Korean population: A prospective clinical, dermoscopic and histopathological study from a single center
| Autor: | Hyun Jeong Park, Jong Sic Kim, Yu Ri Woo, Miri Kim |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms Ingenol mebutate Fitzpatrick Skin Type III Antineoplastic Agents Dermoscopy Dermatology Administration Cutaneous Single Center 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Republic of Korea Humans Medicine Prospective Studies Prospective cohort study Aged Skin Aged 80 and over business.industry Korean population Actinic keratosis General Medicine Middle Aged medicine.disease Keratosis Actinic Treatment Outcome chemistry 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Histopathology Fitzpatrick Skin Type IV Diterpenes business Carcinoma in Situ |
| Zdroj: | The Journal of Dermatology. 45:1324-1330 |
| ISSN: | 0385-2407 |
| DOI: | 10.1111/1346-8138.14632 |
| Popis: | Actinic keratosis (AK) is an in situ squamous cell carcinoma which is mostly found on sun-damaged skin, and it is prevalent among Caucasians. However, there is a lack of research on evaluating the treatment efficacy of ingenol mebutate (IM) on AK in Asians. This study was intended to analyze the treatment outcomes of IM on AK in Korean patients with regards to clinical, dermoscopic and histopathological aspects. A prospective study on 46 Korean patients who were diagnosed with AK and treated with IM was conducted. Clinically, 80% (24/30) of the patients showed an improvement at 8 weeks. Twenty out of the 30 (66.7%) patients were found to have achieved histopathological clearance. All local skin responses had disappeared at T4 in all patients. Patients with Fitzpatrick skin type III were proven to exhibit better treatment outcomes, both clinically (P = 0.001) and histopathologically (P = 0.001), than those with Fitzpatrick skin type IV. The clinical and histopathological clearance rate of AK with IM in Korean patients was 80% and 66.7%, respectively. The patients with Fitzpatrick skin type IV showed a tendency to have residual AK, histopathologically after treatment with IM. In conclusion, IM could be an effective and safe treatment option on AK in Korean patients. In addition, it would be helpful to carry out a cautious check-up when treating AK with IM in patients with a darker skin color. |
| Databáze: | OpenAIRE |
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