Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton
| Autor: | Robert K. Rude, H. James Norton, Barbara G. Mills, Helen E. Gruber, Angelica Frausto, Livia Y. Wei |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Pathology lcsh:Diseases of the musculoskeletal system Bone density 030309 nutrition & dietetics Appendicular skeleton chemistry.chemical_element 030209 endocrinology & metabolism Mice 03 medical and health sciences 0302 clinical medicine Rheumatology Bone Density Internal medicine Magnesium deficiency (medicine) Animals Medicine Magnesium Orthopedics and Sports Medicine Femur Quantitative computed tomography Bone mineral Mice Inbred BALB C 0303 health sciences medicine.diagnostic_test business.industry Body Weight medicine.disease Diet Endocrinology medicine.anatomical_structure chemistry Female Cortical bone lcsh:RC925-935 business Magnesium Deficiency Research Article |
| Zdroj: | BMC Musculoskeletal Disorders BMC Musculoskeletal Disorders, Vol 4, Iss 1, p 7 (2003) |
| ISSN: | 1471-2474 |
| Popis: | Background Dietary magnesium (Mg) deficiency in the mouse perturbs bone and mineral homeostasis. The objective of the present study was to evaluate bone mineral density of the femur in control and Mg-deficient mice. Methods BALB/c mice aged 28 days at study initiation were maintained on a normal or Mg deficient (0.0002% Mg) diet, and at time points 0, 2, 4 or 6 weeks bones were harvested for bone mineral density analysis. Peripheral quantitative computed tomography (pQCT) was used to assess the trabecular metaphyseal compartment and the cortical midshaft. Results Although mean total bone density of the femoral midshaft in Mg deficient mice did not differ significantly from controls throughout the study, the trabecular bone compartment showed significantly decreased mineral content after 4 (p < 0.001) and 6 weeks (p < 0.001) of Mg depletion. Conclusions This study demonstrates the profound effect of Mg depletion on the trabecular compartment of bone, which, with its greater surface area and turnover, was more responsive to Mg depletion than cortical bone in the appendicular skeleton of the mouse. |
| Databáze: | OpenAIRE |
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