Multicentre standardisation of chest MRI as radiation-free outcome measure of lung disease in young children with cystic fibrosis
Autor: | Sandra Barth, Oyunbileg von Stackelberg, Mark O. Wielpütz, Michael Puderbach, Burkhard Tümmler, Hans-Ulrich Kauczor, Marcus A. Mall, Monika Eichinger, Isabell Ricklefs, Christian Schneider, Mirjam Stahl, Bertram J. Jobst, Jens Vogel-Claussen, Matthias V. Kopp, Lutz Nährlich, Christian Dopfer, Michael Buchholz |
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Rok vydání: | 2018 |
Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Cystic Fibrosis Response to therapy Cystic fibrosis 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Germany Outcome Assessment Health Care medicine Humans Lung medicine.diagnostic_test business.industry Outcome measures Infant Magnetic resonance imaging Mean age Radiation Exposure Reference Standards medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure 030228 respiratory system Diagnostic quality Lung disease Child Preschool Pediatrics Perinatology and Child Health Feasibility Studies Female Radiology business |
Zdroj: | Journal of Cystic Fibrosis. 17:518-527 |
ISSN: | 1569-1993 |
Popis: | Background A recent single-centre study demonstrated that MRI is sensitive to detect early abnormalities in the lung and response to therapy in infants and preschool children with cystic fibrosis (CF) supporting MRI as an outcome measure of early CF lung disease. However, the feasibility of multicentre standardisation remains unknown. Objective To determine the feasibility of multicentre standardisation of chest MRI in infants and preschool children with CF. Methods A standardised chest 1.5 T MRI protocol was implemented across four specialised CF centres. Following training and initiation visits, 42 infants and preschool children (mean age 3.2 ± 1.5 years, range 0–6 years) with clinically stable CF underwent MRI and chest X-ray (CXR). Image quality and lung abnormalities were assessed using a standardised questionnaire and an established CF MRI and CXR score. Results MRI was successfully performed with diagnostic quality in all patients (100%). Incomplete lung coverage was observed in 6% and artefacts also in 6% of sequence acquisitions, but these were compensated by remaining sequences in all patients. The range of the MRI score in CF patients was similar across centres with a mean global MRI score of 13.3 ± 5.8. Cross-validation of the MRI against the CXR score revealed a moderate correlation (r = 0.43–0.50, p Conclusion Our results demonstrate that multicentre standardisation of chest MRI is feasible and support its use as radiation-free outcome measure of lung disease in infants and preschool children with CF. |
Databáze: | OpenAIRE |
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