Augmenting Glioblastoma Chemotherapy with Polymers
| Autor: | Carol L. Nilsson, Matthew Skinner, Todd Emrick, Sarah M. Ward |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Polymers
Physiology Cognitive Neuroscience medicine.medical_treatment Brain tumor Antineoplastic Agents Pharmacology Biochemistry 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine medicine Humans Chemotherapy Temozolomide Brain Neoplasms business.industry Cancer Cell Biology General Medicine medicine.disease 030220 oncology & carcinogenesis Cancer research Glioblastoma business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | ACS Chemical Neuroscience. 9:8-10 |
| ISSN: | 1948-7193 |
| DOI: | 10.1021/acschemneuro.7b00168 |
| Popis: | Chemotherapeutics are vital for treating brain tumors such as glioblastoma, an aggressive and prolific cancer predominantly treated with DNA alkylating agents. The efficacy of antiglioblastoma drugs, such as temozolomide, is limited by their rapid clearance and instability under normal physiological conditions. Both local and systemic polymer-based therapeutics have shown promise for treating many cancers, and as such there is a growing interest in applying polymer techniques to augment the efficacy and stability of glioblastoma chemotherapeutics. Notably, brain tumor chemotherapy presents unique challenges and will require tailored delivery systems to develop markedly improved treatments. |
| Databáze: | OpenAIRE |
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