Interaction of the yeast omnipotent suppressors SUP1(SUP45) and SUP2(SUP35) with non-mendelian factors
| Autor: | A R Dagkesamanskaya, M D Ter-Avanesyan |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Non-Mendelian inheritance
Genes Recessive Saccharomyces cerevisiae Investigations Biology medicine.disease_cause Guanidines Plasmid Genetics medicine Allele Genes Suppressor Gene Alleles Guanidine Genes Dominant Mutation Null allele Phenotype Blotting Southern Transformation (genetics) Protein Biosynthesis Genes Lethal Plasmids |
| Zdroj: | Genetics. 128:513-520 |
| ISSN: | 1943-2631 |
| Popis: | The SUP1 and SUP2 genes code for protein factors intimately involved in the control of translational accuracy. The disrupted alleles of these genes confer a recessive lethal phenotype in both [psi+] and [psi-] genetic backgrounds, indicating an essential function for the corresponding proteins. In [psi+] diploids, heterozygous for the SUP1 null allele, several dominant phenotypes were evident with slow growth and inability to sporulate. These dominant phenotypes disappear after transformation with the multicopy plasmid carrying the wild-type allele of the SUP1 gene. Such dominant phenotypes were not observed for the SUP2 null allele. The incompatibility of multicopy plasmids carrying the SUP2 gene with guanidine hydrochloride-curable cytoplasmic factor(s) was also demonstrated. The possible mechanisms of interaction of the SUP1 and SUP2 genes with the [psi] determinant are discussed. |
| Databáze: | OpenAIRE |
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