Should first-line empiric treatment strategies cover coagulase-negative Staphylococcal infections in severely malnourished or HIV-infected children in Kenya

Autor: Anna C. Seale, Kelsey D. J. Jones, James A. Berkley, Shebe Mohammed, Greg Fegan, Christina W. Obiero, Neema Mturi, Susan C. Morpeth, Charlotte L. Bendon, Moses Ngari
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
RNA viruses
Pediatrics
Physiology
Staphylococcus
lcsh:Medicine
Bacteremia
HIV Infections
Pathology and Laboratory Medicine
Families
Immunodeficiency Viruses
Contaminants
Medicine and Health Sciences
Blood culture
lcsh:Science
Children
2. Zero hunger
Antiinfective agent
Multidisciplinary
Blood Volume
medicine.diagnostic_test
cons
Kwashiorkor
Staphylococcal Infections
3. Good health
Anti-Bacterial Agents
Body Fluids
Bacterial Pathogens
Blood
Medical Microbiology
Child
Preschool

Viral Pathogens
Viruses
Physical Sciences
Female
Pathogens
Anatomy
Research Article
Coagulase
medicine.medical_specialty
030106 microbiology
Severe Acute Malnutrition
Materials Science
Microbiology
03 medical and health sciences
Retroviruses
medicine
Parasitic Diseases
Humans
Microbial Pathogens
Materials by Attribute
Nutrition
business.industry
lcsh:R
Lentivirus
Organisms
Infant
Biology and Life Sciences
HIV
medicine.disease
Tropical Diseases
Kenya
Malaria
Malnutrition
Age Groups
People and Places
lcsh:Q
Population Groupings
business
Serostatus
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0182354 (2017)
ISSN: 1932-6203
Popis: BACKGROUND: Bloodstream infection is a common cause of morbidity in children aged METHODS: Systematically collected clinical and microbiological surveillance data from children aged 6-59 months admitted to Kilifi County Hospital (2007-2013) were analysed. Multivariable regression was used to test associations between CoNS isolation from blood cultures and SAM (MUAC RESULTS: CoNS were isolated from blood culture in 906/13,315 (6.8%) children, of whom 135/906 (14.9%) had SAM and 54/906 (6.0%) were HIV antibody positive. CoNS isolation was not associated with SAM (MUACCONCLUSION: In a large, systematic study, there was no evidence that antimicrobial therapy should specifically target CoNS amongst children with SAM or HIV-infection or exposure.
Databáze: OpenAIRE