Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop
| Autor: | Fatah Kashanchi, T. Kevin Howcroft, Lillian S. Kuo, Robert L. Raffai, Hakho Lee, John P. Nolan, Kang Li, Francisco Sánchez-Madrid, Yoel Sadovsky, Huiping Liu, Thomas R. Gingeras, Peter Kurre, Stefan Momma, Tania B. Lombo, Kasey C. Vickers, Rodosthenis S. Rodosthenous, Kenneth W. Witwer, Kayla M. Valdes, Alissa M. Weaver, Stephen Jay Gould, Saumya Das, Joshua N. Leonard, D. Michiel Pegtel, Yong Zeng, Margaret J. Ochocinska |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Biomedical Review Cell Communication Translational Research Biomedical 03 medical and health sciences Translational Research Animals Humans State of the science RNA metabolism Animal Extramural General Medicine Congresses as Topic Priority areas Data science United States Clinical Practice Disease Models Animal 030104 developmental biology Gene Expression Regulation National Institutes of Health (U.S.) Disease Models RNA Extracellular Space Extracellular RNA |
| Zdroj: | Li, K, Rodosthenous, R S, Kashanchi, F, Gingeras, T, Gould, S J, Kuo, L S, Kurre, P, Lee, H, Leonard, J N, Liu, H, Lombo, T B, Momma, S, Nolan, J P, Ochocinska, M J, Pegtel, D M, Sadovsky, Y, Sánchez-Madrid, F, Valdes, K M, Vickers, K C, Weaver, A M, Witwer, K W, Zeng, Y, Das, S, Raffai, R L & Howcroft, T K 2018, ' Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop ', JCI Insight, vol. 3, no. 7 . https://doi.org/10.1172/jci.insight.98942 JCI insight, vol 3, iss 7 Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid |
| ISSN: | 2379-3708 |
| Popis: | Extracellular RNA (exRNA) has emerged as an important transducer of intercellular communication. Advancing exRNA research promises to revolutionize biology and transform clinical practice. Recent efforts have led to cutting-edge research and expanded knowledge of this new paradigm in cell-to-cell crosstalk; however, gaps in our understanding of EV heterogeneity and exRNA diversity pose significant challenges for continued development of exRNA diagnostics and therapeutics. To unravel this complexity, the NIH convened expert teams to discuss the current state of the science, define the significant bottlenecks, and brainstorm potential solutions across the entire exRNA research field. The NIH Strategic Workshop on Extracellular RNA Transport helped identify mechanistic and clinical research opportunities for exRNA biology and provided recommendations on high priority areas of research that will advance the exRNA field. |
| Databáze: | OpenAIRE |
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