Tumor-associated metabolic and inflammatory responses in early stage non-small cell lung cancer: Local patterns and prognostic significance
Autor: | Carlos Alvarez, Ana Belén Enguita, Julio Sánchez de Cos, Roldán Cortés, Luis Seijo, Cristina Balcells, Eduard Monsó, Esther Barreiro, Marta Cascante, Anabel Martinez-Romero, Ramon Rami-Porta, Laura Millares |
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Rok vydání: | 2018 |
Předmět: |
Male
0301 basic medicine Pulmonary and Respiratory Medicine Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Early-stage Inflammation NSCLC Cohort Studies 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung PDL1 Internal medicine Biomarkers Tumor medicine Humans Stage (cooking) Lung cancer Pentose phosphate pathway Aged Neoplasm Staging Retrospective Studies Tissue microarray business.industry Retrospective cohort study Middle Aged Prognosis medicine.disease Survival Analysis Gene Expression Regulation Neoplastic 030104 developmental biology Tissue Array Analysis 030220 oncology & carcinogenesis Adenocarcinoma Immunohistochemistry Female IL1β Tumor necrosis factor alpha Inflammation Mediators Transketolase medicine.symptom business Signal Transduction |
Zdroj: | Recercat. Dipósit de la Recerca de Catalunya instname |
ISSN: | 0169-5002 |
Popis: | INTRODUCTION: Non-small cell lung cancer (NSCLC) patients diagnosed in early stage and surgically-treated have five-year mortality rate >20%. The identification of biomarkers able to predict progression and death may help to identify patients needing closer follow-up. METHODS: A retrospective cohort of early-stage surgically-treated NSCLC patients enrolled in the International Association for the Study of Lung Cancer (IASLC) Staging Project was created, and tissue Microarrays (TMAs) were constructed with tumor and non-tumor lung tissue. Pentose phosphate pathway (PPP) proteins (transketolase [TKT] and transketolase-like 1 [TKTL1]), inflammatory markers (cyclooxygenase-2 [COX-2], tumor necrosis factor alpha [TNF-α], interleukin 1 beta [IL1β], nuclear factor kappa-light-chain-enhancer of activated B cells [NFκB]-p65 and antigen Ki-67), and programmed death-ligand 1 (PDL1) were measured by immunohistochemistry. RESULTS: NSCLC patients with adenocarcinoma (ADC) or squamous cell carcinoma (SCC) were included in the study (n = 199). TKT and TKTL1 were significantly higher in ADC than in non-tumor tissue (p 30% above those of non-tumor tissue (p |
Databáze: | OpenAIRE |
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