Tumor-associated metabolic and inflammatory responses in early stage non-small cell lung cancer: Local patterns and prognostic significance

Autor: Carlos Alvarez, Ana Belén Enguita, Julio Sánchez de Cos, Roldán Cortés, Luis Seijo, Cristina Balcells, Eduard Monsó, Esther Barreiro, Marta Cascante, Anabel Martinez-Romero, Ramon Rami-Porta, Laura Millares
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Pulmonary and Respiratory Medicine
Oncology
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Early-stage
Inflammation
NSCLC
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Carcinoma
Non-Small-Cell Lung
PDL1
Internal medicine
Biomarkers
Tumor
medicine
Humans
Stage (cooking)
Lung cancer
Pentose phosphate pathway
Aged
Neoplasm Staging
Retrospective Studies
Tissue microarray
business.industry
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
Survival Analysis
Gene Expression Regulation
Neoplastic
030104 developmental biology
Tissue Array Analysis
030220 oncology & carcinogenesis
Adenocarcinoma
Immunohistochemistry
Female
IL1β
Tumor necrosis factor alpha
Inflammation Mediators
Transketolase
medicine.symptom
business
Signal Transduction
Zdroj: Recercat. Dipósit de la Recerca de Catalunya
instname
ISSN: 0169-5002
Popis: INTRODUCTION: Non-small cell lung cancer (NSCLC) patients diagnosed in early stage and surgically-treated have five-year mortality rate >20%. The identification of biomarkers able to predict progression and death may help to identify patients needing closer follow-up. METHODS: A retrospective cohort of early-stage surgically-treated NSCLC patients enrolled in the International Association for the Study of Lung Cancer (IASLC) Staging Project was created, and tissue Microarrays (TMAs) were constructed with tumor and non-tumor lung tissue. Pentose phosphate pathway (PPP) proteins (transketolase [TKT] and transketolase-like 1 [TKTL1]), inflammatory markers (cyclooxygenase-2 [COX-2], tumor necrosis factor alpha [TNF-α], interleukin 1 beta [IL1β], nuclear factor kappa-light-chain-enhancer of activated B cells [NFκB]-p65 and antigen Ki-67), and programmed death-ligand 1 (PDL1) were measured by immunohistochemistry. RESULTS: NSCLC patients with adenocarcinoma (ADC) or squamous cell carcinoma (SCC) were included in the study (n = 199). TKT and TKTL1 were significantly higher in ADC than in non-tumor tissue (p 30% above those of non-tumor tissue (p
Databáze: OpenAIRE
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