Methylene blue--a promising treatment modality in sepsis induced by bowel perforation
| Autor: | Y. Wollman, M.Y. Rabau, S. Marmur, Z. Mianski, T. Chernikovsky, Yair Galili, D. Soffer, J.P. Klausner, A. Iaina, Y. Kluger |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Pathology Perforation (oil well) Peritonitis Lung injury Nitric Oxide Gastroenterology Nitroarginine Sepsis Internal medicine medicine Animals Respiratory function Enzyme Inhibitors Rats Wistar Diffuse alveolar damage Lung business.industry Septic shock medicine.disease Rats Methylene Blue medicine.anatomical_structure Intestinal Perforation Surgery business |
| Zdroj: | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. 29(5) |
| ISSN: | 0014-312X |
| Popis: | In this study, we compared the effects of methylene blue (MB) and an L-arginine analogue on host outcome, blood pressure, lung injury, and nitric oxide (NO) production in rats following fecal peritonitis induced by cecal ligation and puncture (CLP). Sepsis syndrome was induced in 90 rats: 30 were treated with MB, 30 with an NO synthase inhibitor, and 30 with normal saline. We found significantly less alveolar damage, higher blood pressure, better respiratory function, and delayed mortality among animals treated with MB compared to the control group. We conclude that the ability of MB to reduce alveolar damage and therefore to delay mortality in this animal septic shock model may give this harmless substance a role among the treatment modalities of septic shock syndrome induced by fecal peritonitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|