Vitamin D ratio and glycaemic control in individuals with type 2 diabetes mellitus: A systematic review
| Autor: | Liliane Viana Pires, Paula Nascimento Brandão-Lima, Ramara Kadija Fonseca Santos, Analícia Rocha Santos Freire, Raissa Maria Dumas Delatore Tete |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Population 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Gastroenterology vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Internal Medicine Vitamin D and neurology Medicine Humans Vitamin D education education.field_of_study business.industry Insulin Quantitative insulin sensitivity check index Type 2 Diabetes Mellitus Vitamins medicine.disease Hypoglycemia chemistry Diabetes Mellitus Type 2 Hyperglycemia business Cholecalciferol |
| Zdroj: | Diabetes/metabolism research and reviews. 34(3) |
| ISSN: | 1520-7560 |
| Popis: | Several studies have suggested a favorable role for vitamin D in glycaemic metabolism and its potential as adjuvant treatment of type 2 diabetes mellitus. This review discusses the role of vitamin D in the glycaemic control of individuals with type 2 diabetes mellitus and evaluates the effect of vitamin D supplementation on glycaemic markers in this population. Literature searches were performed in the BIREME, LILACS, and PubMed databases using the Medical Subject Headings and words related to vitamin D, type 2 diabetes mellitus, and glycaemic control. Interventional and observational studies were considered eligible. The evaluation of the included studies was independently performed by 2 evaluators at all stages of selection, data extraction, and bias risk assessment. The primary outcome was the relationship between vitamin D levels and glucose metabolism markers in type 2 diabetes mellitus individuals. The secondary outcome was the effect of vitamin D supplementation on the glycaemic control markers in individuals with type 2 diabetes mellitus. The inverse relationship between vitamin D and variables of glucose metabolism was verified. Interventional studies revealed that vitamin D supplementation did not alter glycaemic control markers in most studies. Few studies have shown positive effects with a significant reduction in the percentage of glycated haemoglobin, insulin, and glucose concentrations, and changes in homeostatic model assessment-insulin resistance and beta cell, and quantitative insulin sensitivity check index. Therefore, despite the association of vitamin D with glucose metabolism, there is insufficient evidence of the beneficial effects of its supplementation on the metabolic control of type 2 diabetes mellitus. |
| Databáze: | OpenAIRE |
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