Comparison of continuous versus intermittent enteral nutrition in critically ill patients (COINN): study protocol for a randomized comparative effectiveness trial
| Autor: | Kamil Vrbica, Petr Suk, Ondrej Hrdy, Igor Sas, Radka Stepanova, Lenka Součková, Roman Gál, Eva Strazevska |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Diarrhea medicine.medical_specialty Vomiting Critical Illness Medicine (miscellaneous) law.invention Study Protocol 03 medical and health sciences Enteral Nutrition 0302 clinical medicine law Humans Medicine Intensive care unit Pharmacology (medical) 030212 general & internal medicine Intensive care medicine Randomized Controlled Trials as Topic Adult patients business.industry Critically ill Gastric residual volume 030208 emergency & critical care medicine Clinical trial Intensive Care Units Critical care Parenteral nutrition medicine.symptom business Protein target |
| Zdroj: | Trials |
| ISSN: | 1745-6215 |
| Popis: | Background Enteral nutrition is part of the treatment of critically ill patients. Administration of enteral nutrition may be associated with signs of intolerance, such as high gastric residual volumes, diarrhea, and vomiting. Clinical trials regarding the effects of the mode of administration of enteral nutrition on the occurrence of these complications have yielded conflicting results. This trial aims to investigate whether the mode of administration of enteral nutrition affects the time to reach nutritional targets, intolerance, and complications. Methods COINN is a randomized, monocentric study for critically ill adult patients receiving enteral nutrition. Patients will be randomly assigned to two groups receiving (1) continuous or (2) intermittent administration of enteral nutrition. Enhancement of enteral nutrition will depend on signs of tolerance, mainly the gastric residual volume. The primary outcome will be the time to reach the energetic target. Secondary outcomes will be the time to reach the protein target, tolerance, complications, hospital and ICU lengths of stay, and 28-day mortality. Discussion This trial aims to evaluate whether the mode of application of enteral nutrition affects the time to reach nutritional targets, signs of intolerance, and complications. Trial registration ClinicalTrials.gov NCT03573453. Registered on 29 June 2018 |
| Databáze: | OpenAIRE |
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