Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: Possible implication for neurodegenerative diseases
| Autor: | Herman Devijver, Christian Gestreau, Lies Gielis, Gérard Hilaire, Clément Menuet, Nicolas Voituron, Mathias Dutschmann, Peter Borghgraef, Fred Van Leuven |
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| Rok vydání: | 2012 |
| Předmět: |
Tau protein
Mice Transgenic NMDA receptors lcsh:RC321-571 Mice Mice Neurologic Mutants Alzheimer Disease Memantine medicine Animals Anesthesia Cognitive decline lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Nucleus ambiguus Upper airways Isoflurane biology business.industry Neurodegeneration medicine.disease Disease Models Animal Tauopathy Tauopathies Neurology Anesthetics Inhalation Nerve Degeneration Anesthetic biology.protein Respiratory Insufficiency business Brain Stem medicine.drug |
| Zdroj: | Neurobiology of Disease, Vol 46, Iss 1, Pp 234-243 (2012) |
| ISSN: | 0969-9961 |
| DOI: | 10.1016/j.nbd.2012.01.012 |
| Popis: | article i nfo The postoperative cognitive decline resulting from volatile anesthesia is gaining acceptance as a major health problem. The common anesthetic isoflurane is suspected to precipitate neurodegeneration in Alzheimer's disease by unknown mechanisms. We previously validated that 8 month old Tau.P301L mice suffer upper air- ways defects related to tauopathy within the Kolliker-Fuse nucleus that controls upper airways function. We now report that isoflurane anesthesia in young, pre-symptomatic Tau.P301L mice triggered precocious upper airways defects and tauopathy in several brainstem nuclei, including the nucleus ambiguus that contains upper airways motor neurons and the Kolliker-Fuse. The prescription drug memantine, identified as an NMDA receptor antagonist, prevented the post-anesthesia upper airways dysfunction and alleviated tauopa- thy in the nucleus ambiguus and Kolliker-Fuse. We further identified protocols of anesthesia in young Tau.P301L mice that mitigated adverse effects of isoflurane anesthesia. Thus, our experimental findings in a validated mouse model for tauopathy demonstrate the link between isoflurane anesthesia, earlier onset of tauopathy and earlier onset of functional deficits, highlight the implication of NMDA-receptors in the mech- anisms mediating the adverse effects of isoflurane, and potentially identify safer protocols for anesthesia in patients with tauopathy. |
| Databáze: | OpenAIRE |
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