A Crossover Study of Risperidone in Children, Adolescents and Adults with Mental Retardation
| Autor: | Jennifer R. Zarcone, Stephen R. Schroeder, Janet Marquis, Kandace Fleming, Jessica A. Hellings, R. Matthew Reese, Maria G. Valdovinos |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent medicine.drug_class Psychological intervention Atypical antipsychotic Weight Gain Irritability Double-Blind Method Intellectual Disability Developmental and Educational Psychology medicine Humans Autistic Disorder Child Cross-Over Studies Risperidone Mental Disorders Middle Aged medicine.disease Crossover study Aggression Developmental disorder Mood Autism Female medicine.symptom Psychology Antipsychotic Agents Clinical psychology medicine.drug |
| Zdroj: | Journal of Autism and Developmental Disorders. 36:401-411 |
| ISSN: | 1573-3432 0162-3257 |
| Popis: | Risperidone has shown safety and efficacy for aggressive and destructive behaviors in short-term studies. This longer-duration study includes a broad sample. Forty subjects, aged 8-56 years (mean=22), all with mental retardation and 36 with autism spectrum disorders participated in this 22-week crossover study, with 24 weeks of open maintenance thereafter. Of 40 subjects, 23 (57.5%) responded fully (50% decrease in Aberrant Behavior Checklist-Community Irritability subscale score), while 35 subjects (87.5%) showed a 25% decrease. Gender, mood disorder, and antiseizure medications did not alter response. Increased appetite and weight gain were common. Low dose risperidone was effective for aggressive behavior in persons with MR. More long-term studies are needed, incorporating weight control interventions. |
| Databáze: | OpenAIRE |
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