Biological and pharmacological effects and nutritional impact of phytosterols: A comprehensive review

Autor: Saeedeh Talebi, Maryam Khosravi, Elyas Nattagh-Eshtivani, Hanieh Barghchi, Rahele Ziaei, Abed Ghavami, Yasaman Amiri, Pishva Arzhang, Naseh Pahlavani, Mehdi Barati, Abdulmannan Fadel
Rok vydání: 2021
Předmět:
Zdroj: Phytotherapy Research. 36:299-322
ISSN: 1099-1573
0951-418X
Popis: Phytosterols (PSs), classified into plant sterols and stanols, are bioactive compounds found in foods of plant origin. PSs have been proposed to exert a wide number of pharmacological properties, including the potential to reduce total and low-density lipoprotein (LDL) cholesterol levels and thereby decreasing the risk of cardiovascular diseases. Other health-promoting effects of PSs include anti-obesity, anti-diabetic, anti-microbial, anti-inflammatory, and immunomodulatory effects. Also, anticancer effects have been strongly suggested, as phytosterol-rich diets may reduce the risk of cancer by 20%. The aim of this review is to provide a general overview of the available evidence regarding the beneficial physiological and pharmacological activities of PSs, with special emphasis on their therapeutic potential for human health and safety. Also, we will explore the factors that influence the physiologic response to PSs.
Databáze: OpenAIRE
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