Multiple sclerosis and faecal microbiome transplantation: are you going to eat that?
| Autor: | A.C. Wing, M. Kremenchutzky |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Multiple Sclerosis Disease Gut flora Microbiology law.invention 03 medical and health sciences Probiotic 0302 clinical medicine Immune system law Medicine Humans Microbiome biology Host Microbial Interactions business.industry Multiple sclerosis Probiotics Fecal Microbiota Transplantation biology.organism_classification medicine.disease Gastrointestinal Microbiome Transplantation Intestines 030104 developmental biology Immunology Dysbiosis business 030217 neurology & neurosurgery |
| Zdroj: | Beneficial microbes. 10(1) |
| ISSN: | 1876-2891 |
| Popis: | Gut microbiome interaction goes beyond commensal function as vitamin production or support nutrients digestion. It also interplays with the host immune system and may be related to the development of immune-mediated diseases. Multiple sclerosis patients have dysbiosis compared to healthy individuals. But how this relates to disease development and severity is still uncertain. Dietary change including probiotic mixtures or ketogenic regimen has proven to change microbiome in multiple sclerosis (MS) subjects to one similar to healthy controls. However, proof of clinical benefits is lacking. We dissert on current knowledge about immune system and gut bacteria interactions. We discuss faecal microbial transplantation as a potential intervention to ameliorate gut dysbiosis in MS as well as the caveats of a clinical trial design. |
| Databáze: | OpenAIRE |
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