Long-term effectiveness and cost-effectiveness of high versus low-to-moderate intensity resistance and endurance exercise interventions among cancer survivors
| Autor: | Mai J. M. Chinapaw, Judith E. Bosmans, Anita Vreugdenhil, J. M. van Dongen, Johannes Brug, Goof Schep, W. van Mechelen, Caroline S. Kampshoff, Laurien M. Buffart, Jos W. R. Twisk |
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| Přispěvatelé: | Kindergeneeskunde, MUMC+: MA Medische Staf Kindergeneeskunde (9), RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Health Economics and Health Technology Assessment, APH - Health Behaviors & Chronic Diseases, APH - Mental Health, APH - Methodology, AMS - Ageing and Morbidity, Methodology and Applied Biostatistics, Medical oncology, Division 6, Public and occupational health, Epidemiology and Data Science, ACS - Atherosclerosis & ischemic syndromes, CCA - Cancer Treatment and quality of life, Amsterdam Reproduction & Development (AR&D), APH - Societal Participation & Health |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
FITNESS Cost effectiveness Cost-Benefit Analysis medicine.medical_treatment Physical fitness FATIGUE law.invention 0302 clinical medicine Cancer Survivors Quality of life Randomized controlled trial law QUALITY-OF-LIFE Neoplasms 030212 general & internal medicine Fatigue Netherlands Rehabilitation INSTRUMENT Oncology (nursing) Health Care Costs Middle Aged RANDOMIZED CONTROLLED-TRIAL Exercise Therapy Endurance Training Treatment Outcome Cardiorespiratory Fitness Oncology 030220 oncology & carcinogenesis CHEMOTHERAPY REACT Female Exercise intensity Adult REHABILITATION medicine.medical_specialty Article 03 medical and health sciences SDG 3 - Good Health and Well-being Endurance training medicine Humans BREAST-CANCER Muscle Strength METAANALYSIS business.industry Resistance Training Cardiorespiratory fitness PHYSICAL-ACTIVITY Physical therapy Cost-effectiveness business |
| Zdroj: | Kampshoff, C S, van Dongen, J M, van Mechelen, W, Schep, G, Vreugdenhil, A, Twisk, J W R, Bosmans, J E, Brug, J, Chinapaw, M J M & Buffart, L M 2018, ' Long-term effectiveness and cost-effectiveness of high versus low-to-moderate intensity resistance and endurance exercise interventions among cancer survivors ', Journal of cancer survivorship, vol. 12, no. 3, pp. 1-13 . https://doi.org/10.1007/s11764-018-0681-0 Kampshoff, C S, van Dongen, J M, van Mechelen, W, Schep, G, Vreugdenhil, A, Twisk, J W R, Bosmans, J E, Brug, J, Chinapaw, M J M & Buffart, L M 2018, ' Long-term effectiveness and cost-effectiveness of high versus low-to-moderate intensity resistance and endurance exercise interventions among cancer survivors ', Journal of Cancer Survivorship, vol. 12, no. 3, pp. 417-429 . https://doi.org/10.1007/s11764-018-0681-0 Journal of Cancer Survivorship-Research and Practice, 12(3), 417-429. Springer, Cham Journal of Cancer Survivorship Journal of cancer survivorship, 12(3), 1-13. Springer New York Journal of Cancer Survivorship, 12(3), 417-429. Springer New York |
| ISSN: | 1932-2259 |
| Popis: | Purpose: This study aimed to evaluate the long-term effectiveness and cost-effectiveness of high intensity (HI) versus low-to-moderate intensity (LMI) exercise on physical fitness, fatigue, and health-related quality of life (HRQoL) in cancer survivors. Methods: Two hundred seventy-seven cancer survivors participated in the Resistance and Endurance exercise After ChemoTherapy (REACT) study and were randomized to 12 weeks of HI (n = 139) or LMI exercise (n = 138) that had similar exercise types, durations, and frequencies, but different intensities. Measurements were performed at baseline (4–6 weeks after primary treatment), and 12 (i.e., short term) and 64 (i.e., longer term) weeks later. Outcomes included cardiorespiratory fitness, muscle strength, self-reported fatigue, HRQoL, quality-adjusted life years (QALYs) and societal costs. Linear mixed models were conducted to study (a) differences in effects between HI and LMI exercise at longer term, (b) within-group changes from short term to longer term, and (c) the cost-effectiveness from a societal perspective. Results: At longer term, intervention effects on role (β = 5.9, 95% CI = 0.5; 11.3) and social functioning (β = 5.7, 95%CI = 1.7; 9.6) were larger for HI compared to those for LMI exercise. No significant between-group differences were found for physical fitness and fatigue. Intervention-induced improvements in cardiorespiratory fitness and HRQoL were maintained between weeks 12 and 64, but not for fatigue. From a societal perspective, the probability that HI was cost-effective compared to LMI exercise was 0.91 at 20,000€/QALY and 0.95 at 52,000€/QALY gained, mostly due to significant lower healthcare costs in HI exrcise. Conclusions: At longer term, we found larger intervention effects on role and social functioning for HI than for LMI exercise. Furthermore, HI exercise was cost-effective with regard to QALYs compared to LMI exercise. Trial registration: This study is registered at the Netherlands Trial Register [NTR2153 [http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2153]] on the 5th of January 2010. Implications for Cancer Survivors: Exercise is recommended to be part of standard cancer care, and HI may be preferred over LMI exercise. |
| Databáze: | OpenAIRE |
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