Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer
Autor: | Tianyu Lu, Jibing Chen, Feng Mu, Kecheng Xu, You-Yong Lu, Xiao-Feng Kong |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms medicine.medical_treatment adverse event Neuroscience (miscellaneous) Antineoplastic Agents chemotherapy NSCLC Targeted therapy PFS Carcinoma Non-Small-Cell Lung Internal medicine Administration Inhalation medicine Humans Progression-free survival Adverse effect Lung cancer Aged Aged 80 and over Chemotherapy targeted drug business.industry Cancer Immunotherapy Middle Aged medicine.disease Anesthesiology and Pain Medicine non-small-cell lung cancer Tumor progression hydrogen Disease Progression Female immunotherapy business progression-free survival Research Article |
Zdroj: | Medical Gas Research |
ISSN: | 2045-9912 |
Popis: | Chemotherapy, targeted therapy, and immunotherapy are used against advanced non-small cell lung cancer. A clinically efficacious method for relieving the adverse events associated of such therapies is lacking. Fifty-eight adult patients were enrolled in our trial to relieve pulmonary symptoms or the adverse events of drugs. Twenty patients who refused drug treatment were assigned equally and randomly to a hydrogen (H2)-only group and a control group. According to the results of tumor-gene mutations and drug-sensitivity tests, 10, 18, and 10 patients were enrolled into chemotherapy, targeted therapy, and immunotherapy groups in which these therapies were combined with H2-therapy, respectively. Patients underwent H2 inhalation for 4–5 hours per day for 5 months or stopped when cancer recurrence. Before study initiation, the demographics (except for tumor-mutation genes) and pulmonary symptoms (except for moderate cough) of the five groups showed no significant difference. During the first 5 months of treatment, the prevalence of symptoms of the control group increased gradually, whereas that of the four treatment groups decreased gradually. After 16 months of follow-up, progression-free survival of the control group was lower than that of the H2-only group, and significantly lower than that of H2 + chemotherapy, H2 + targeted therapy, and H2 + immunotherapy groups. In the combined-therapy groups, most drug-associated adverse events decreased gradually or even disappeared. H2 inhalation was first discovered in the clinic that can be used to control tumor progression and alleviate the adverse events of medications for patients with advanced non-small cell lung cancer. This study was approved by the Ethics Committee of Fuda Cancer Hospital of Jinan University on December 7, 2018 (approval No. Fuda20181207), and was registered at ClinicalTrials.gov (Identifier: NCT03818347) on January 28, 2019. |
Databáze: | OpenAIRE |
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