Malignant peripheral nerve sheath tumours in magnetic resonance imaging: primary and recurrent tumour appearance, post-treatment changes, and metastases
| Autor: | Sam Sedaghat, Maya Sedaghat, Martin Grözinger, Frederick Schmitz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
recurrence 050801 communication & media studies oedema 0508 media and communications medicine In patient Recurrent tumour metastases Lymph node Peripheral Nerve Sheath malignant peripheral nerve sheath tumour Original Paper Lung medicine.diagnostic_test business.industry 05 social sciences Magnetic resonance imaging medicine.disease medicine.anatomical_structure Seroma Radiology Post treatment business appearance MRI |
| Zdroj: | Polish Journal of Radiology |
| ISSN: | 1733-134X |
| Popis: | Purpose: To analyse the appearance of primary and recurrent malignant peripheral nerve sheath tumours (MPNSTs) in magnetic resonance imaging (MRI) with a focus on configuration, and to assess the occurrence of loco-regional post-treatment changes and metastases during post-treatment follow-up. Material and methods: Twenty patients with histologically proven MPNST underwent post-treatment 1.5 T MRI. Primary and recurrent MPNSTs were examined for configuration, contrast enhancement, extent, and signal intensity in MRI. Loco-regional post-treatment changes and information on metastases were extracted from the follow-up. Results: MPNSTs occurred most often in the extremities (p = 0.006). Twenty per cent (n = 4) of the patients developed recurrences, with a total of 24 lesions. Recurrent MPNSTs were significantly smaller than primary MPNSTs (p = 0.003). Primary MPNSTs mostly occurred unifocally as multilobulated or ovoid and heterogeneous lesions with mostly well-defined borders. Recurrent MPNSTs purely occurred multifocally as mostly nodular (p < 0.001), multilobulated, or ovoid lesions. 80%, 65% and 30% of the patients showed post-treatment subcutaneous oedema (p = 0.002 to 0.03), muscle oedema (p = 0.02), and seroma, respectively. Twenty-five per cent (n = 5) of patients presented metastases during follow-up. The relative risk in patients with recurrences to develop lung or lymph node metastases is eightfold (p = 0.056). Conclusions: While primary MPNSTs mostly appear unifocally as multilobulated or ovoid lesions, recurrent MPNSTs purely occur multifocally as mostly nodular lesions. Subcutaneous and muscle oedema are very common locoregional post-treatment changes. Patients with recurrences have a higher risk for lung and lymph node metastases. |
| Databáze: | OpenAIRE |
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